Evidence map›Paper›PMID 39257144›Full record

ReviewCurrent pharmaceutical design2025

Potential Signal Pathways and Therapeutic Effects of Mesenchymal Stem Cell on Oxidative Stress in Diseases.

Yina Xie, Lingqian Zheng, Wenmin Chen, Yang Zeng, Kaijin Yao, Tianbiao Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yina XieDepartment of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Lingqian ZhengDepartment of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Wenmin ChenDepartment of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Yang ZengDepartment of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Kaijin YaoDepartment of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Tianbiao ZhouDepartment of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.

Funding

Provincial Science and Technology Innovation Strategy special project funding program Shanfuke [2021]88-28: 210714086900312
6 · The paper itself

Abstract

Oxidative stress is a biological stress response produced by the destruction of redox equilibrium in aerobic metabolism in organisms, which is closely related to the occurrence of many diseases. Mesenchymal stem cells (MSCs) have been found to improve oxidative stress injury in a variety of diseases, including lung injury, liver diseases, atherosclerotic diseases, diabetes and its complications, ischemia-reperfusion injury, inflammatory bowel disease. The antioxidant stress capacity of MSCs may be a breakthrough in the treatment of these diseases. This review found that MSCs have the ability to resist oxidative stress, which may be achieved through MSCs involvement in mediating the Nrf2, MAPK, NF-κB, AMPK, PI3K/AKT and Wnt4/β-catenin signaling pathways.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationOxidative StressSignal TransductionAnimalsHumansaerobic metabolismliver diseases.Mesenchymal stem celloxidative stressredox equilibriumsignal pathways

Identifiers

PMID39257144

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.