ArticleJournal of magnetic resonance imaging : JMRI2025
Same-Day Repeatability and 28-Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi-Site Trial.
Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- Feasibility and Impact of a Coached Home-Based Exercise Program on Cardiorespiratory Fitness in Adults With Cystic Fibrosis on Highly Effective Modulator Therapy.CHEST pulmonary · 2026Article
- Comparison of Single-Breath and Multi-Breath Xe-MRI in the Longitudinal Assessment of Treatment in Children With Cystic Fibrosis.Journal of magnetic resonance imaging : JMRI · 2026Article
- A longitudinal study of quantitative pulmonary dynamic contrast enhanced MRI following COVID-19 infection.Respiratory research · 2026Article
- Utility of hyperpolarised xenon-129 magnetic resonance imaging in primary ciliary dyskinesia.ERJ open research · 2026Article
- Xenon-129 magnetic resonance imaging detects ongoing ventilation improvements in people with cystic fibrosis receiving highly effective modulator therapy.Annals of the American Thoracic Society · 2026Article
- The emerging role of hyperpolarizedExpert review of respiratory medicine · 2025Article
- Establishing standardized healthy reference distributions and values for multisiteMagnetic resonance in medicine · 2025Article
- Dual-Center Repeatability, Consistency, and Comparison of 3D Phase-Resolved Functional (PREFUL) Ventilation MRI at 3 and 1.5 T in Healthy Volunteers.NMR in biomedicine · 2025Article
- Advances in noninvasive imaging for detecting radiation-induced lung injury (RILI).International journal of radiation biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundMRI with xenon-129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi-site study. PURPOSE: To determine the same-day repeatability and 28-day reproducibility of Xe MRI in children with CF. STUDY TYPE: Four-center prospective, longitudinal. POPULATION: Thirty-eight children (18 females, 47%), median interquartile range (IQR) age 12 (9-14) years old, with mild CF (forced expiratory volume in 1 second (FEV FIELD STRENGTH/SEQUENCE: 3-T, two-dimensional (2D) gradient-echo (GRE) sequence. ASSESSMENT: Xe MRI, FEV STATISTICAL TESTS: Inter-site comparisons were conducted using Kruskal-Wallis nonparametric tests with Dunn's multiple-comparisons tests. Differences for individuals were assessed using Wilcoxon matched-pairs tests. Bland-Altman tests were used to evaluate same-day repeatability, 28-day reproducibility, and inter-reader agreement. A P-value ≤0.05 was considered significant.
resultsMedian FEV DATA
conclusionXe MRI may offer excellent same-day and short-term reproducibility. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.