Evidence mapPaperPMID 39257361Full record

ReviewExpert review of respiratory medicine2024

A clinician's guide to effects of obesity on childhood asthma and into adulthood.

Mahmoud Abu Zahra, Jeffrey Pessin, Deepa Rastogi

Abstract readReview
In one paragraph

Review in Expert review of respiratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mahmoud Abu ZahraDivision of Respiratory and Sleep Medicine, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Jeffrey PessinDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Deepa RastogiDivision of Respiratory and Sleep Medicine, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.

Funding

Relevance of RPS27L expression quantitative trait locus in pediatric obesity-related asthmaR21AI166744 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Deepa Rastogi · 2024 to 2024
$210k
Investigating the CDC42 pathway as a novel pathway for pediatric non-atopic obesity-related asthmaR01HL141849 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI Deepa Rastogi · 2023 to 2023
$0k
NHLBI NIH HHS R01 HL141849NIAID NIH HHS R21 AI166744
6 · The paper itself

Abstract

introductionObesity, one of the most common chronic conditions affecting the human race globally, affects several organ systems, including the respiratory system, where it contributes to onset and high burden of asthma. Childhood onset of obesity-related asthma is associated with high persistent morbidity into adulthood. AREAS COVERED: In this review, we discuss the disease burden in children and adults to highlight the overlap between symptoms and pulmonary function deficits associated with obesity-related asthma in both age ranges, and then discuss the potential role of three distinct mechanisms, that of mechanical fat load, immune perturbations, and of metabolic perturbations on the disease burden. We also discuss interventions, including medical interventions for weight loss such as diet modification, that of antibiotics and anti-inflammatory therapies, as well as that of surgical intervention on amelioration of burden of obesity-related asthma. EXPERT OPINION: With increase in obesity-related asthma due to increasing burden of obesity, it is evident that it is a disease entity distinct from asthma among lean individuals. The time is ripe to investigate the underlying mechanisms, focusing on identifying novel therapeutic targets as well as consideration to repurpose medications effective for other obesity-mediated complications, such as insulin resistance, dyslipidemia and systemic inflammation.

Indexed as

AsthmaPediatric ObesityAdultAge FactorsChildHumansLungObesityRisk FactorsWeight LossadultsAsthmachildrendisease burdenobesitytherapies

Identifiers

PMID39257361
PMCPMC11473229

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.