Evidence map›Paper›PMID 39257666›Full record

ArticleRSC advances2024

Soft X-ray spectromicroscopy of human fibroblasts with impaired sialin function.

Tuomas Mansikkala, Salla M Kangas, Ilkka Miinalainen, Pia Angervaniva, Niklas Darin, Maria Blomqvist, Reetta Hinttala, Marko Huttula, Johanna Uusimaa, Minna Patanen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tuomas MansikkalaNano and Molecular Systems Research Unit, 90014 University of Oulu PO Box 3000 Finland leo.mansikkala@oulu.fi minna.patanen@oulu.fi.ORCID https://orcid.org/0000-0001-8920-7291
Salla M KangasResearch Unit of Clinical Medicine and Medical Research Center, Oulu University Hospital and University of Oulu 90014 Oulu Finland.
Ilkka MiinalainenBiocenter Oulu, 90014 University of Oulu PO Box 5000 Finland.
Pia AngervanivaResearch Unit of Clinical Medicine and Medical Research Center, Oulu University Hospital and University of Oulu 90014 Oulu Finland.
Niklas DarinDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg 40530 Gothenburg Sweden.
Maria BlomqvistDepartment of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Sweden and Department of Clinical Chemistry, Sahlgrenska University Hospital 41345 Gothenburg Sweden.
Reetta HinttalaBiocenter Oulu, 90014 University of Oulu PO Box 5000 Finland.
Marko HuttulaNano and Molecular Systems Research Unit, 90014 University of Oulu PO Box 3000 Finland leo.mansikkala@oulu.fi minna.patanen@oulu.fi.ORCID https://orcid.org/0000-0002-4970-598X
Johanna UusimaaResearch Unit of Clinical Medicine and Medical Research Center, Oulu University Hospital and University of Oulu 90014 Oulu Finland.
Minna PatanenNano and Molecular Systems Research Unit, 90014 University of Oulu PO Box 3000 Finland leo.mansikkala@oulu.fi minna.patanen@oulu.fi.ORCID https://orcid.org/0000-0002-2970-7494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salla disease (SD) is a lysosomal storage disease where free sialic acid (SA) accumulates in lysosomes due to the impaired function of a membrane protein, sialin. Synchrotron radiation-based scanning transmission soft X-ray spectromicroscopy (STXM) was used to analyze both SD patients' fibroblasts and normal human dermal fibroblasts (NHDF) from healthy controls. Both cell lines were also cultured with

Identifiers

PMID39257666
PMCPMC11385984

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.