Evidence map›Paper›PMID 39258169›Full record

ArticleiScience2024

Genome-wide association reveals a locus in neuregulin 3 associated with gabapentin efficacy in women with chronic pelvic pain.

Scott C Mackenzie, Nilufer Rahmioglu, Liana Romaniuk, Frances Collins, Lydia Coxon, Heather C Whalley, Katy Vincent, Krina T Zondervan, Andrew W Horne, Lucy H R Whitaker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Scott C MackenzieCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.
Nilufer RahmiogluWellcome Centre for Human Genetics, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7BN, UK.
Liana RomaniukDivision of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK.
Frances CollinsCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.
Lydia CoxonOxford Endometriosis CaRe Centre, Nuffield Department of Women's & Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Heather C WhalleyDivision of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, UK.
Katy VincentOxford Endometriosis CaRe Centre, Nuffield Department of Women's & Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Krina T ZondervanWellcome Centre for Human Genetics, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7BN, UK.
Andrew W HorneCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.
Lucy H R WhitakerCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.

Funding

Medical Research Council MR/N022556/1
6 · The paper itself

Abstract

Chronic pelvic pain (CPP) in women with no obvious pelvic pathology has few evidence-based treatment options. Our recent multicenter randomized controlled trial (GaPP2) in women with CPP and no obvious pelvic pathology showed that gabapentin did not relieve pain overall and was associated with more side effects than placebo. We conducted an exploratory genome-wide association study using eligible GaPP2 participants aiming to identify genetic variants associated with gabapentin response. One genome-wide significant association with gabapentin analgesic response was identified, rs4442490, an intron variant located in Neuregulin 3 (

Indexed as

Association analysisNeurogeneticsPain management in health technologyQuantitative genetics

Identifiers

PMID39258169
PMCPMC11384074

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.