Evidence map›Paper›PMID 39258406›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2024

Is there a prodrome to NMOSD? An investigation of neurologic symptoms preceding the first NMOSD attack.

Sydney Lee, Ruth Ann Marrie, Giulia Fadda, Mark S Freedman, Liesly Lee, Alexandra Muccilli, Manav V Vyas, Andrea Konig, Dalia L Rotstein

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Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sydney LeeDepartment of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-8591-2062
Ruth Ann MarrieDepartments of Internal Medicine and Community Health Sciences, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-1855-5595
Giulia FaddaDepartment of Medicine, Division of Neurology, University of Ottawa, Ottawa, ON, Canada.
Mark S FreedmanDepartment of Medicine, Division of Neurology, University of Ottawa, Ottawa, ON, Canada.
Liesly LeeDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Alexandra MuccilliDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Manav V VyasDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-2953-2540
Andrea KonigDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Dalia L RotsteinDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is unknown whether people with aquaporin-4 antibody positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) experience a prodrome, although a few cases report AQP4 + serology up to 16 years before the first attack.

objectivesTo evaluate whether individuals with AQP4-IgG + NMOSD have prodromal neurologic symptoms preceding the first attack.

methodsWe reviewed medical records of participants meeting the 2015 diagnostic criteria for AQP4-IgG + NMOSD from four demyelinating disease centres in the Canadian NMOSD cohort study CANOPTICS. We searched for neurologic symptoms occurring at least 30 days before the first attack.

resultsOf 116 participants with NMOSD, 17 (14.7%) had prodromal neurologic symptoms. The median age was 48 years (range 25-83) at first attack; 16 (94.1%) were female. Participants presented with numbness/tingling (

conclusionsOne in seven people with NMOSD experienced neurologic symptoms before their first attack. Further investigation of a possible NMOSD prodrome is warranted.

Indexed as

Aquaporin 4Neuromyelitis OpticaProdromal SymptomsAdultAgedAged, 80 and overAutoantibodiesFemaleHumansImmunoglobulin GMaleMiddle AgedAQP4 protein, humanAquaporin 4AutoantibodiesImmunoglobulin Gdemyelinating diseasesneuroinflammatory diseasesNeuromyelitis optica spectrum disorderprodrome

Identifiers

PMID39258406
PMCPMC11529114

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.