Evidence map›Paper›PMID 39258805›Full record

ArticleCNS neuroscience & therapeutics2024

Neuroimaging analysis reveals distinct cerebral perfusion responses to fasting-postprandial metabolic switching in Alzheimer's disease patients.

Runzhi Li, Zhizheng Zhuo, Zeshan Yao, Zhaohui Li, Yanli Wang, Jiwei Jiang, Linlin Wang, Wenyi Li, Yanling Zhang, Jun Sun and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Runzhi LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhizheng ZhuoDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zeshan YaoJingjinji national center of technology innovation, Beijing, China.
Zhaohui LiBioMind Inc, Beijing, China.
Yanli WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jiwei JiangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Linlin WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wenyi LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yanling ZhangDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jun SunDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Junjie LiDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yunyun DuanDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yi LiuShanxi Key Laboratory of Brain Disease Control, Shanxi Provincial People's Hospital, Taiyuan, China.
Hongyuan ShaoShanxi Key Laboratory of Brain Disease Control, Shanxi Provincial People's Hospital, Taiyuan, China.
Yang LiDepartment of Neurology, First Hospital, Shanxi Medical University, Taiyuan, China.
Yechuan ZhangDepartment of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK.
Jinglong ChenDepartment of Geriatric Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Hanping ShiDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Hui HuangDepartment of Head and Neck Surgical Oncology, National Cancer Centre/National Clinical Research Centre for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yaou LiuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-9930-0331
Jun XuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-7432-6781

Funding

Guangzhou Planned Project of Science and Technology 202201020343National Key Research and Development Program of China 2021YFC2500100National Key Research and Development Program of China 2021YFC2500103National Key Research and Development Program of China 2022YFC2009904National Natural Science Foundation of China 81870821National Natural Science Foundation of China 82071187Open Project of Shanxi Key Laboratory of Brain Disease Control BDC202204Shanxi Province Science Foundation for Youths 202203021222360
6 · The paper itself

Abstract

aimsExtended fasting-postprandial switch intermitting time has been shown to affect Alzheimer's disease (AD). Few studies have investigated the cerebral perfusion response to fasting-postprandial metabolic switching (FMS) in AD patients. We aimed to evaluate the cerebral perfusion response to FMS in AD patients.

methodsIn total, 30 AD patients, 32 mild cognitive impairment (MCI) patients, and 30 healthy control individuals (HCs) were included in the quantification of cerebral perfusion via cerebral blood flow (CBF). The cerebral perfusion response to FMS was defined as the difference (ΔCBF) between fasting and postprandial CBF.

resultsPatients with AD had a regional negative ΔCBF in the anterior temporal lobe, part of the occipital lobe and the parietal lobe under FMS stimulation, whereas HCs had no significant ΔCBF. The AD patients had lower ΔCBF values in the right anterior temporal lobe than the MCI patients and HCs. ΔCBF in the anterior temporal lobe was negatively correlated with cognitive severity and cognitive reserve factors in AD patients.

conclusionsAD patients exhibited a poor ability to maintain cerebral perfusion homeostasis under FMS stimulation. The anterior temporal lobe is a distinct area that responds to FMS in AD patients and negatively correlates with cognitive function.

Indexed as

Alzheimer DiseaseCerebrovascular CirculationCognitive DysfunctionFastingPostprandial PeriodAgedAged, 80 and overBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingAlzheimer's diseasecerebral blood flowcognitive functionfastingintermittent fasting

Identifiers

PMID39258805
PMCPMC11388574

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.