Evidence map›Paper›PMID 39259352›Full record

ArticleAging clinical and experimental research2024

The association between physical activity and delayed neurocognitive recovery in elderly patients: a mediation analysis of pro-inflammatory cytokines.

Junfang Niu, Yanan Li, Qi Zhou, Xiang Liu, Peixia Yu, Fang Gao, Xia Gao, Qiujun Wang

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655687 (Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655687 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery: a Multicenter Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2028Enrolled1,512ConditionsElderly Patients, Cancer Surgery, Hypothermia, Accidental, Targeted Temperature ManagementArmsTarget temperature management, Routine thermal management
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junfang NiuDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, China.
Yanan LiDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, China.
Qi ZhouDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, China.
Xiang LiuDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, China.
Peixia YuDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, China.
Fang GaoDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, China.
Xia GaoDepartment of Epidemiology and Statistics & Hebei Province Key Laboratory of Environment and Human Health, School of Public Health, Hebei Medical University, Shijiazhuang, China.
Qiujun WangDepartment of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, China. 37000628@hebmu.edu.cn.

Funding

Hebei Province Graduate Professional Degree Quality Teaching Case Library Construction Project KCJPZ2023022the Hebei Provincial Science and Technology Department's Precision Medicine Joint Fund Key Project H2021206021
6 · The paper itself

Abstract

backgroundDelayed neurocognitive recovery (dNCR) can result in unfavorable outcomes in elderly surgical patients. Physical activity (PA) has been shown to improve cognitive function, potentially by reducing systemic inflammatory responses. However, there is a lack of supportive data indicating whether PA has a protective effect against dNCR.

aimsTo examine the correlation between dNCR and PA, and to further analyze if pro-inflammatory cytokines mediate this relationship.

methodsThis study is a prospective nested case-control investigation of elderly patients who had knee replacement surgery. dNCR was defined as a decline in cognitive function compared with baseline by using a battery of neuropsychological tests. PA was assessed with the Physical Activity Scale for the Elderly (PASE). Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum concentrations of IL-6, IL-1β, and TNF-α. Multivariable logistic regression analysis was conducted to assess the association between PA and dNCR. Mediation analysis was employed to evaluate whether pro-inflammatory cytokines mediate the relationship between them.

resultsA cohort of 152 patients was included, resulting in an incidence rate of dNCR of 23.68%. PA was associated with dNCR after full adjustment [OR = 0.199, (95% CI, 0.061; 0.649), P = 0.007]. Mediation analysis showed that the IL-6 mediated the statistical association between PA and dNCR, with mediation proportions (%) of 77.68 (postoperative concentration of IL-6) or 27.58 (the absolute change in IL-6 before and after surgery).

conclusionsPA serves as a protective factor against dNCR, possibly through the reduction of pro-inflammatory cytokine concentrations. THE CHINESE CLINICAL TRAIL REGISTRY: : www.http://chictr.org.cn , Registration No. ChiCTR2300070834, Registration date: April 24, 2023.

Indexed as

CytokinesExerciseAgedAged, 80 and overArthroplasty, Replacement, KneeCase-Control StudiesCognitionFemaleHumansMaleMediation AnalysisNeuropsychological TestsProspective StudiesCytokinesDelayed neurocognitive recoveryElderly patientPhysical activityPro-inflammatory cytokinesSedentary behavior

Identifiers

PMID39259352
PMCPMC11390811

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.