Evidence map›Paper›PMID 39259404›Full record

Trial reportHormones (Athens, Greece)2025

Spirulina supplementation and circuit resistance training (CRT) reduce serum asprosin and appetite and improve energy balance in men with obesity and overweight.

Nakhaei Hossein, Mogharnasi Mehdi, Dehghani Karim, Mohammadi Mahdi, Elham Ghasemi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Hormones (Athens, Greece), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nakhaei HosseinHealth Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Mogharnasi MehdiFaculty of Sport Sciences, University of Birjand, Birjand, Iran.
Dehghani KarimUniversity of Birjand, Birjand, Iran.
Mohammadi MahdiHealth Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Elham GhasemiDepartment of Sport Sciences, Faculty of Literature and Humanities, University of Zabol, Zabol, Iran. elhamghasemi@uoz.ac.ir.ORCID http://orcid.org/0000-0001-8643-486X

Funding

Zahedan University of Medical Sciences 9838
6 · The paper itself

Abstract

purposeThe present study aimed to investigate the effects of 8 weeks spirulina supplementation and circuit resistance training (CRT) on asprosin, appetite, and energy balance in men with obesity and overweight.

methodsThe study comprised a single-blind randomized controlled trial. Sixty men with obesity and overweight (BMI > 25) were selected and randomly divided into four equal groups (n = 15 each) of training plus spirulina, training plus placebo, spirulina, and placebo. The participants of the training groups performed 12 movements with 40-90% maximal repetition (three sessions per week) and the supplemental groups consumed 1000 mg of spirulina per day for 8 weeks. Asprosin, appetite using visual analog scales, calorie intake, energy expenditure, and body composition were measured before and after the intervention. To analyze the data, the paired sample t-test, analysis of covariance, Bonferroni post-hoc, and Pearson correlation tests were employed using SPSS (version 20) at a significance level of p < 0.05.

resultsAfter the intervention, asprosin level (P = 0.015, P = 0.015, and P = 0.020, respectively), weight (P < 0.001, P < 0.001, and P < 0.001, respectively), calorie intake (P = 0.015, P = 0.011, and P = 0.004, respectively), and hunger (P = 0.011, P = 0.015, and P = 0.015, respectively) declined in the training plus spirulina, training plus placebo, and spirulina groups (p < 0.05). In addition, energy expenditure (P = 0.012 and P = 0.015, respectively) and fullness (P = 0.015 and P = 0.011, respectively) increased in the training plus spirulina and training plus placebo groups. The mean changes of the research indicators in the training plus spirulina group were significantly more than those of the other groups (p < 0.001).

conclusionIt was shown that 8 weeks of CRT and spirulina supplementation decreases the level of asprosin and improves appetite and energy balance in men with obesity and overweight.

Indexed as

AppetiteDietary SupplementsEnergy MetabolismFibrillin-1ObesityOverweightPeptide FragmentsResistance TrainingSpirulinaAdipokinesAdultEnergy IntakeHumansMaleMiddle AgedSingle-Blind MethodAdipokinesFBN1 protein, humanFibrillin-1Peptide FragmentsAppetiteAsprosinObesityResistance trainingSpirulina

Identifiers

PMID39259404

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.