Evidence map›Paper›PMID 39259676›Full record

ArticleBiochemistry2024

DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η.

Rachana Tomar, Pratibha P Ghodke, Amritraj Patra, Elizabeth Smyth, Alexander Pontarelli, William Copp, F Peter Guengerich, John C Chaput, Christopher J Wilds, Michael P Stone and 1 more

Abstract read
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rachana TomarDepartment of Chemistry, Vanderbilt Ingram Cancer Center, and Vanderbilt Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
Pratibha P GhodkeDepartment of Biochemistry, School of Medicine, Vanderbilt Ingram Cancer Center, and Vanderbilt Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Amritraj PatraDepartment of Biochemistry, School of Medicine, Vanderbilt Ingram Cancer Center, and Vanderbilt Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Elizabeth SmythDepartment of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B 1R6, Canada.
Alexander PontarelliDepartment of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B 1R6, Canada.
William CoppDepartment of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B 1R6, Canada.
F Peter GuengerichDepartment of Biochemistry, School of Medicine, Vanderbilt Ingram Cancer Center, and Vanderbilt Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0002-7458-3048
John C ChaputDepartment of Pharmaceutical Sciences, University of California, Irvine, California 92697, United States.ORCID 0000-0003-1393-135X
Christopher J WildsDepartment of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B 1R6, Canada.ORCID 0000-0002-0336-4753
Michael P StoneDepartment of Chemistry, Vanderbilt Ingram Cancer Center, and Vanderbilt Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-0922-0216
Martin EgliDepartment of Biochemistry, School of Medicine, Vanderbilt Ingram Cancer Center, and Vanderbilt Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0003-4145-356X

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
DNA Adduct-Induced MutagenesisR01ES029357 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2018 to 2022
$2.6M
DNA Adduct-Induced MutagenesisR56ES029357 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2024 to 2024
$250k
NCI NIH HHS P01 CA160032NCI NIH HHS P30 CA068485NIEHS NIH HHS R01 ES029357NIEHS NIH HHS R56 ES029357
6 · The paper itself

Abstract

α-l-(3'-2')-Threofuranosyl nucleic acid (TNA) pairs with itself, cross-pairs with DNA and RNA, and shows promise as a tool in synthetic genetics, diagnostics, and oligonucleotide therapeutics. We studied

Indexed as

DNA-Directed DNA PolymeraseDNA ReplicationCrystallography, X-RayDNAHumansModels, MolecularNucleotidesY-Family DNA PolymerasesDNADNA-Directed DNA PolymeraseNucleotidesRad30 proteinY-Family DNA Polymerases

Identifiers

PMID39259676
PMCPMC11447838

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.