Evidence map›Paper›PMID 39259761›Full record

ArticleMolecular biology of the cell2024

The prolyl isomerase FKBP11 is a secretory translocon accessory factor.

Amanda DiGuilio, Ben Cheng, Frank Zhong, Roshan Jha, Yu Wan, S Andrei Anghel, Hong Hu, Evgenia Shishkova, Zhe Ji, Joshua J Coon and 1 more

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amanda DiGuilioDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.
Ben ChengDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.
Frank ZhongDepartment of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637.
Roshan JhaDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.
Yu WanDepartment of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60628.
S Andrei AnghelDepartment of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637.
Hong HuCenter for Research Informatics, The University of Chicago, Chicago, IL 60637.
Evgenia ShishkovaNational Center for Quantitative Biology of Complex Systems, Madison, WI 53706.
Zhe JiDepartment of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60628.
Joshua J CoonNational Center for Quantitative Biology of Complex Systems, Madison, WI 53706.
Robert J KeenanDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.

Funding

Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Membrane protein biogenesis at the ERR35GM145374 · NIGMS · UNIVERSITY OF CHICAGO · PI Robert J Keenan · 2022 to 2026
$3.5M
Characterizing functional translation in putative 'noncoding' regions of a genome: Admin SupplR35GM138192 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JI, ZHE · 2020 to 2024
$2.1M
An ultra-low-input RNase footprinting assay to quantify cytosolic and mitochondrial translation simultaneouslyR01HL161389 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JI, ZHE · 2022 to 2025
$1.9M
Biogenesis of multi-pass membrane proteins at the ERR01GM130051 · NIGMS · UNIVERSITY OF CHICAGO · PI KEENAN, ROBERT J · 2018 to 2021
$1.3M
NHLBI NIH HHS R01 HL161389NIDDK NIH HHS P30 DK020595NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R01 GM130051NIGMS NIH HHS R35 GM138192NIGMS NIH HHS R35 GM145374NIGMS NIH HHS T32 GM007183
6 · The paper itself

Abstract

Eukaryotic cells encode thousands of secretory and membrane proteins, many of which are cotranslationally translocated into the endoplasmic reticulum (ER). Nascent polypeptides entering the ER encounter a network of molecular chaperones and enzymes that facilitate their folding. A rate-limiting step for some proteins is the

Indexed as

Endoplasmic ReticulumPeptidylprolyl IsomeraseProtein TransportRibosomesTacrolimus Binding ProteinsHEK293 CellsHeLa CellsHumansMembrane ProteinsProtein BindingProtein BiosynthesisProtein FoldingMembrane ProteinsPeptidylprolyl IsomeraseTacrolimus Binding Proteins

Identifiers

PMID39259761
PMCPMC11617091

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.