Evidence map›Paper›PMID 39259764›Full record

ArticleMolecular biology of the cell2024

Big1 is a newly identified autophagy regulator that is critical for a fully functional V-ATPase.

Yuchen Lei, Ying Yang, Zhihai Zhang, Ruoxi Zhang, Xinxin Song, Sami N Malek, Daolin Tang, Daniel J Klionsky

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [ATPase HZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuchen LeiLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216.ORCID 0000-0003-2112-4144
Ying YangLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216.
Zhihai ZhangLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216.
Ruoxi ZhangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xinxin SongDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sami N MalekInternal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109-0936.
Daolin TangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Daniel J KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216.ORCID 0000-0002-7828-8118

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

The vacuolar-type H

Indexed as

AutophagyLysosomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVacuolar Proton-Translocating ATPasesVacuolesMutationSignal TransductionTOR Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsTOR Serine-Threonine KinasesVacuolar Proton-Translocating ATPases

Identifiers

PMID39259764
PMCPMC11617096

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.