Evidence map›Paper›PMID 39260416›Full record

ArticleNature2024

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.

Diana Arseni, Takashi Nonaka, Max H Jacobsen, Alexey G Murzin, Laura Cracco, Sew Y Peak-Chew, Holly J Garringer, Ito Kawakami, Hisaomi Suzuki, Misumoto Onaya and 9 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. TDP-43 Aggregation: The Healthy-Toxic Balance of the Prion-Like Domain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Nuclear dysfunction in aging and neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Diana ArseniMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0001-7585-288X
Takashi NonakaDepartment of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Max H JacobsenDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-3344-898X
Alexey G MurzinMRC Laboratory of Molecular Biology, Cambridge, UK.
Laura CraccoDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Sew Y Peak-ChewMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-7602-6384
Holly J GarringerDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-1899-7676
Ito KawakamiDepartment of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Hisaomi SuzukiDepartment of Psychiatry, National Hospital Organization Shimofusa Psychiatric Center, Chiba, Japan.
Misumoto OnayaDepartment of Psychiatry, National Hospital Organization Shimofusa Psychiatric Center, Chiba, Japan.
Yuko SaitoDepartment of Neuropathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Shigeo MurayamaDepartment of Neuropathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Changiz GeulaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ruben VidalDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Kathy L NewellDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-1648-7357
Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Masato HasegawaDepartment of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID 0000-0001-7415-8159
Benjamin Ryskeldi-FalconMRC Laboratory of Molecular Biology, Cambridge, UK. bfalcon@mrc-lmb.cam.ac.uk.ORCID 0000-0002-8176-2618

Funding

Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROGALSKI, EMILY J · 1996 to 2020
$28.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SANDRA WEINTRAUB · 2021 to 2026
$26.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
ASYMMETRIC NEURODEGENERATION AND LANGUAGE IN PRIMARY PROGRESSIVE APHASIAR01AG077444 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAREK-MARSEL M MESULAM, EMILY J ROGALSKI · 2022 to 2026
$10.4M
Language in Primary Progressive AphasiaR01DC008552 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MESULAM, MAREK-MARSEL M · 2007 to 2021
$8.5M
Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical PhenotypeR01NS085770 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEULA, CHANGIZ · 2014 to 2024
$5.0M
Determinants of neurodegenerative decline in the aphasic variant of Alzheimer's diseaseR01AG056258 · NIA · UNIVERSITY OF CHICAGO · PI ROGALSKI, EMILY J · 2017 to 2022
$4.1M
Structure of amyloid fibrils in human neurodegenerative diseases and agingRF1NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2023 to 2023
$3.9M
Atomic models of human tau filaments and development of tau ligandsU01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2018 to 2022
$3.5M
Investigating the role of TDP-43 mislocalization, structure, and post-translational modifications in the neuropathologically heterogeneous TDP-43 proteinopathiesR01NS137469 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI Laura Cracco, Kathy L Newell · 2024 to 2026
$3.0M
Identification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation.R01AG080001 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BERNARDINO Francesco GHETTI, RUBEN VIDAL · 2023 to 2026
$2.7M
Structural analysis of tau associated with parenchymal and vascular prion protein amyloidosisRF1AG071177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2021 to 2021
$2.3M
NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG056258NIA NIH HHS R01 AG071177NIA NIH HHS R01 AG077444NIA NIH HHS R01 AG080001NIA NIH HHS RF1 AG071177NIDCD NIH HHS R01 DC008552NINDS NIH HHS R01 NS085770NINDS NIH HHS R01 NS137469NINDS NIH HHS RF1 NS110437NINDS NIH HHS U01 NS110437
6 · The paper itself

Abstract

Neurodegenerative diseases are characterized by the abnormal filamentous assembly of specific proteins in the central nervous system

Indexed as

AmyloidAnnexinsBrainDNA-Binding ProteinsFrontotemporal DementiaAphasiaCryoelectron MicroscopyHumansModels, MolecularProtein MultimerizationAmyloidAnnexinsANXA11 protein, humanDNA-Binding ProteinsTARDBP protein, human

Identifiers

PMID39260416
PMCPMC11485244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.