Evidence map›Paper›PMID 39261545›Full record

ArticleScientific reports2024

Reduced retinol (vitamin A) and α-tocopherol (vitamin E) blood levels and increased myeloperoxidase (MPO) activity in children with high myopia.

Bozena Mikoluc, Jolanta Sawicka-Powierza, Klaudia Berk, Mateusz Maciejczyk, Katarzyna Powierza, Anna Zalewska, Julita Szulimowska, Justyna MacDonald, Alicja Koput, Joanna Karpinska and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bozena MikolucDepartment of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, Białystok, Poland. bozenam@mp.pl.
Jolanta Sawicka-PowierzaDepartment of Family Medicine, Medical University of Bialystok, Białystok, Poland.
Klaudia BerkDepartment of Physiology, Medical University of Bialystok, Białystok, Poland.
Mateusz MaciejczykDepartment of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Białystok, Poland.
Katarzyna PowierzaDepartment of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Anna ZalewskaExperimental Dentistry Laboratory, Medical University of Bialystok, Białystok, Poland.
Julita SzulimowskaDepartment of Conservative Dentistry, Medical University of Bialystok, Białystok, Poland.
Justyna MacDonaldDepartment of Foreign Languages, Medical University of Bialystok, Białystok, Poland.
Alicja KoputDepartment of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland.
Joanna KarpinskaFaculty of Chemistry, University of Bialystok, Białystok, Poland.
Roza SawczukFaculty of Chemistry, University of Bialystok, Białystok, Poland.
Marta HryniewickaFaculty of Chemistry, University of Bialystok, Białystok, Poland.
Alina Bakunowicz-LazarczykDepartment of Pediatric Ophthalmology and Strabismus, Medical University of Bialystok, Białystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study assessed selected parameters of redox status in the plasma of patients suffering from high myopia (HM). Thirty-five children with mean age 13.7 ± 2.7 years with HM and 40 healthy children were included. Plasma redox status parameters were determined using colorimetric kits. The levels of retinol, α-tocopherol and coenzyme Q10 were determined with a high-performance liquid chromatograph. Negative correlations were observed between the concentrations of retinol and the axial length of the eye (r = - 0.514 p < 0.001). Increased myeloperoxidase (MPO) activity (p < 0.018), and decreased concentrations of retinol (p < 0.001) and α-tocopherol (p < 0.023) in patients with HM and the axial length of the eye > 26 mm compared to controls were established. Significantly lower retinol and α-tocopherol concentrations were found in patients with the axial length of the eye > 26 mm compared to those with the axial length of the eye ≤ 26 mm (p < 0.001, p < 0.021, respectively). Increased MPO activity in advanced stages of HM may confirm an inflammatory process in HM patients. Reduced retinol and α-tocopherol concentrations and their link to disease progression indicate a need for monitoring their levels and supplementation in children with HM.

Indexed as

alpha-TocopherolMyopiaPeroxidaseVitamin AAdolescentCase-Control StudiesChildFemaleHumansMalealpha-TocopherolPeroxidaseVitamin A

Identifiers

PMID39261545
PMCPMC11390734

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.