Evidence map›Paper›PMID 39261733›Full record

ArticleNature2024

A brain-to-gut signal controls intestinal fat absorption.

Qianqian Lyu, Wenzhi Xue, Ruixin Liu, Qinyun Ma, Vikram Babu Kasaragod, Shan Sun, Qian Li, Yanru Chen, Mingyang Yuan, Yuying Yang and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Treatment with saponins fromNutrition research and practice · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Selective modulation of murine intestinal MAmerican journal of physiology. Cell physiology · 2026
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Qianqian Lyu *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.ORCID 0009-0008-5070-2920
Wenzhi Xue *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.ORCID 0000-0003-3453-1726
Ruixin Liu *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.ORCID 0000-0002-5526-6717
Qinyun Ma *Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Vikram Babu Kasaragod *MRC Laboratory of Molecular Biology, Cambridge, UK.
Shan Sun *Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Qian LiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Yanru ChenDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Mingyang YuanDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.ORCID 0000-0003-2657-6676
Yuying YangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.ORCID 0000-0001-5167-3262
Bing ZhangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.ORCID 0000-0001-8556-8049
Aifang NieDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Sheng JiaDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Chongrong ShenDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Po GaoDepartment of Anatomy and Physiology, SJTUSM, Shanghai, China.ORCID 0000-0002-2860-3239
Weifang RongDepartment of Anatomy and Physiology, SJTUSM, Shanghai, China.
Chenxi YuThe Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yufang BiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Chunlei ZhangInstitut Pasteur, Université de Paris, Neural Circuits for Spatial Navigation and Memory, Paris, France.ORCID 0000-0003-1296-1370
Fajun NanThe Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Guang NingDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Zihe RaoShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Xiuna YangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.ORCID 0000-0003-3443-9815
Jiqiu WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. wangjq@shsmu.edu.cn.ORCID 0000-0002-9383-7656
Weiqing WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. wqingw@shsmu.edu.cn.ORCID 0000-0001-6027-3084

Funding

Medical Research Council MC_UP_1201/15
6 · The paper itself

Abstract

Although fat is a crucial source of energy in diets, excessive intake leads to obesity. Fat absorption in the gut is prevailingly thought to occur organ-autonomously by diffusion

Indexed as

Brain-Gut AxisFatsIntestinal AbsorptionAnimalsIsoflavonesJejunumMaleMedulla OblongataMiceMice, Inbred C57BLMicrovilliNeuronsObesityReceptors, GABA-AVagus NerveWeight GainFatsGabra1 protein, mouseIsoflavonespuerarinReceptors, GABA-A

Identifiers

PMID39261733

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.