ArticleBrain and behavior2024
Association between geriatric nutritional risk index and cognitive function in older adults with/without chronic kidney disease.
Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A nutritional-inflammatory index for early prediction of inpatient urinary tract infection risk after acute stroke in the elderly.The Canadian journal of urology · 2026Article
- Article
- Joint Associations of the Geriatric Nutrition Risk Index and Frailty with All-Cause and Cause-Specific Mortality in Diabetes Patients: A Prospective Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- The Effect of Diabetes Medication on the Scores of the GNRI and CONUT Nutritional Indices: Cross-Sectional and Longitudinal Retrospective Studies.Clinical and translational science · 2025Article
- Prevalence and associated factors of cognitive frailty in older patients with lung cancer undergoing chemotherapy: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Comparison of Body Mass Index Range Criteria and Their Association with Nutrition-Related Risk: A Cross-Sectional Study in Polish Older Adults.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Predictive value of Geriatric Nutritional Risk Index for overall survival in maintenance hemodialysis patients.Frontiers in nutrition · 2025Article
- Associations between nutritional status and cognitive impairment in older adults: results from the NHANES 2011-2014 cycles.Frontiers in nutrition · 2025Article
- Predictive Value of Geriatric Nutritional Risk Index for Readmission within 6-Months in Elderly Inpatients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Association between geriatric nutritional risk index and cognitive function in older adults with/without chronic kidney disease.Brain and behavior · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundCognitive impairment is highly prevalent among patients with chronic kidney disease, who face an increased risk of cognitive decline. The aim of this study was to investigate the relationship between the Geriatric Nutritional Risk Index (GNRI) and cognitive function in older individuals, both with and without chronic kidney disease (CKD).
methodsIn this study, we analyzed data from 2728 participants in the 2011-2014 National Health and Nutrition Examination Survey (NHANES). Cognitive function was measured using the Consortium to Establish a Registry for the Alzheimer's Disease Word Learning subtest (CERAD W-L), the animal fluency test (AFT), the digit symbol substitution test (DSST), and the global cognitive z-score. The GNRI, representing whole-body nutritional status, was calculated based on serum albumin, body weight, and ideal body weight. We employed weighted multiple linear regression analyses and subgroup analyses to assess the independent association of GNRI with cognitive function in CKD and non-CKD populations. Smoothing techniques were used to fit curves, and interaction tests were used to assess the robustness and specificity of the findings.
resultsOur analyses revealed a significant positive association between higher GNRI levels and cognitive function in the older US population (for global z-score: β = 0.01; 95% confidence interval [CI] = 0.00, 0.01). This association remained consistent across various subgroup analyses, including those for different gender groups, age groups, smoking statuses, diabetes statuses, hypertension statuses, individuals with a BMI below 25, individuals who consumed alcohol, and non-Hispanic white individuals. Smoothed curve-fitting analyses indicated that the GNRI was linearly related to cognitive function. No statistically significant interactions were detected among these variables.
conclusionOur findings emphasize the positive association between GNRI and cognitive health in individuals with or without CKD, especially when combined with other risk factors. Consequently, enhancing the nutritional status of the elderly may serve as a viable strategy to thwart the onset of cognitive decline.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.