Evidence map›Paper›PMID 39262341›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Artificial gravity: an effective countermeasure for microgravity-induced headward fluid shift?

Larry A Kramer, Khader M Hasan, Xu Zhang, Edwin Mulder, Darius A Gerlach, Karina Marshall-Goebel, Brandon R Macias, Steven S Laurie, Gary Strangman, Raj Iyer and 1 more

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Larry A KramerDepartment of Diagnostic Imaging and Intervention, McGovern Medical School, UTHealth Houston, Houston, Texas, United States.ORCID 0000-0002-1450-9479
Khader M HasanDepartment of Diagnostic Imaging and Intervention, McGovern Medical School, UTHealth Houston, Houston, Texas, United States.
Xu ZhangCenter for Clinical and Translational Sciences, McGovern Medical School, UTHealth Houston, Houston, Texas, United States.
Edwin MulderResearch, Relationships and Development, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.
Darius A GerlachCardiovascular Aerospace Medicine, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.ORCID 0000-0001-7044-6065
Karina Marshall-GoebelBiomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, Texas, United States.ORCID 0000-0002-5240-7625
Brandon R MaciasCardiovascular and Vision Laboratory, NASA Johnson Space Center, Houston, Texas, United States.ORCID 0000-0003-2527-5089
Steven S LaurieCardiovascular and Vision Laboratory, Kellogg, Brown and Root, Houston, Texas, United States.ORCID 0000-0002-8794-3583
Gary StrangmanMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Raj IyerDepartment of Diagnostic Imaging and Intervention, McGovern Medical School, UTHealth Houston, Houston, Texas, United States.
Eric M BershadDepartment of Neurology and Neurosurgery, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0003-4091-2031

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
Deutsches Zentrum für Luft- und Raumfahrt (DLR) 2475HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR003167National Aeronautics and Space Administration (NASA) NNJ15ZSA001N-AGBRNCATS NIH HHS UL1 TR003167
6 · The paper itself

Abstract

Long-duration spaceflight is associated with pathophysiological changes in the intracranial compartment hypothetically linked to microgravity-induced headward fluid shift. This study aimed to determine whether daily artificial gravity (AG) sessions can mitigate these effects, supporting its application as a countermeasure to spaceflight. Twenty-four healthy adult volunteers (16 men) were exposed to 60 days of 6° head-down tilt bed rest (HDTBR) as a ground-based analog of chronic headward fluid shift. Subjects were divided equally into three groups: no AG (control), daily 30-min intermittent AG (iAG), and daily 30-min continuous (cAG). Internal carotid artery (ICA) stroke volume (ICA

Indexed as

Bed RestFluid ShiftsGravity, AlteredHead-Down TiltWeightlessnessAdultBrainCerebrovascular CirculationFemaleHumansMaleSpace FlightWeightlessness CountermeasuresYoung Adultartificial gravityhead-down tilt bedrestmicrogravityMRIspaceflight-associated neuro-ocular syndrome

Identifiers

PMID39262341
PMCPMC11563643

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.