Evidence map›Paper›PMID 39262376›Full record

ArticleGut microbes

Fecal microbiota transplantation derived from mild cognitive impairment individuals impairs cerebral glucose uptake and cognitive function in wild-type mice:

Tao Wang, Ling Hao, Kexin Yang, Wenjing Feng, Zhiting Guo, Miao Liu, Rong Xiao

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tao WangSchool of Public Health, Capital Medical University, Beijing, China.
Ling HaoSchool of Public Health, Capital Medical University, Beijing, China.
Kexin YangSchool of Public Health, Capital Medical University, Beijing, China.
Wenjing FengSchool of Public Health, Capital Medical University, Beijing, China.
Zhiting GuoSchool of Public Health, Capital Medical University, Beijing, China.
Miao LiuSchool of Public Health, Capital Medical University, Beijing, China.
Rong XiaoSchool of Public Health, Capital Medical University, Beijing, China.ORCID 0000-0002-0603-9518

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiome dysbiosis has been widely implicated in cognitive impairment, but the identity of the specific bacterial taxa and mechanisms are not fully elucidated. Brain glucose hypometabolism coincides with the cognitive decline. This study explored the link among cognition, gut microbiota and glucose uptake based on the fecal microbiota transplantation from mild cognitive impairment individuals (MCI-FMT) and investigated whether similar mechanisms were involved in 27-hydroxycholesterol (27-OHC)-induced cognitive decline. Our results showed that the MCI-FMT mice exhibited learning and memory decline and morphological lesions in the brain and colon tissues. There were reduced

Indexed as

BacteroidetesBrainCognitionCognitive DysfunctionDysbiosisFecal Microbiota TransplantationGastrointestinal MicrobiomeGlucoseSignal TransductionAnimalsCarrier ProteinsGlucose Transport Proteins, FacilitativeHumansMaleMiceMice, Inbred C57BLCarrier ProteinsGlucoseGlucose Transport Proteins, FacilitativeThioredoxinsTxnip protein, mouse27-hydroxycholesterolBacteroidetescerebral glucose uptakecognitive declineFecal microbiota transplantationTXNIP

Identifiers

PMID39262376
PMCPMC11404573

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.