Evidence map›Paper›PMID 39262880›Full record

ReviewAmerican journal of lifestyle medicine

The Role of Physical Exercise in Cognitive Preservation: A Systematic Review.

Matt Kaufman, Paige Dyrek, Michael Fredericson, Marily Oppezzo, Megan Roche, Levi Frehlich, Douglas Noordsy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of lifestyle medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Clinical Effectiveness of Treatments for Mild Cognitive Impairment in Adults: A Systematic Review.European journal of investigation in health, psychology and education · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matt KaufmanDivision of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, Stanford University, Redwood City, CA, USA (MK, PD, MF).
Paige DyrekDivision of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, Stanford University, Redwood City, CA, USA (MK, PD, MF).ORCID https://orcid.org/0000-0001-8871-9703
Michael FredericsonDivision of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, Stanford University, Redwood City, CA, USA (MK, PD, MF).
Marily OppezzoDepartment of Medicine, Prevention Research Center, Stanford University, Palo Alto, CA, USA (MO).
Megan RocheDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA (MR).
Levi FrehlichCumming School of Medicine, University of Calgary, Calgary, AB, Canada (LF).ORCID https://orcid.org/0000-0002-4099-0657
Douglas NoordsyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA (DN).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia, or major neurocognitive disorder, is one of the most common causes of disability and dependency in older adults with far-reaching social, physical, and economic impacts. In the absence of adequate treatment, much research has been directed towards prevention. Physical exercise has been shown to increase cerebral blood flow, amplify production of neurotrophic factors, and enhance brain volume. Whether these changes on a structural and cellular level result in cognitive preservation is less clear. This systematic review synthesizes findings from seventeen randomized controlled trials that examine the effects of physical activity on global cognition, memory, and executive function in older adults. Cognitive benefits of exercise are strongest for those who are cognitively intact or with mild cognitive impairment. In studies with long-term follow up, cognitive gains tended to decay after cessation of physical intervention suggesting that sustained physical exercise may be required to preserve cognitive function in older adults prior to onset of dementia.

Indexed as

activitycognitiondementiaexercisepreservation

Identifiers

PMID39262880
PMCPMC11384842

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.