Evidence map›Paper›PMID 39263222›Full record

ArticleFrontiers in immunology2024

Changes in monocyte subsets in volunteers who received an oral wild-type

Franklin R Toapanta, Jingping Hu, Kari Ann Shirey, Paula J Bernal, Myron M Levine, Thomas C Darton, Claire S Waddington, Andrew J Pollard, Marcelo B Sztein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Franklin R ToapantaDepartment of Medicine and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Jingping HuDepartment of Medicine and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Kari Ann ShireyDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Paula J BernalDepartment of Medicine and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Myron M LevineDepartment of Medicine and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Thomas C DartonOxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre, Oxford, United Kingdom.
Claire S WaddingtonOxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre, Oxford, United Kingdom.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre, Oxford, United Kingdom.
Marcelo B SzteinDepartment of Medicine and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.

Funding

Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FRASER, CLAIRE M. · 2009 to 2018
$27.8M
Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
IMMUNE MECHANISMS OF PROTECTION IN S TYPHI VACCINESR01AI036525 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1994 to 2026
$12.2M
Systems Biology and Biostatistics CoreU19AI181108 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosangela Mezghanni · 2024 to 2026
$8.0M
NIAID NIH HHS R01 AI036525NIAID NIH HHS U19 AI082655NIAID NIH HHS U19 AI109776NIAID NIH HHS U19 AI181108
6 · The paper itself

Abstract

An oral Controlled Human Infection Model (CHIM) with wild-type

Indexed as

MonocytesSalmonella typhiTyphoid FeverAdultFemaleHumansMacrophagesMaleYoung AdultCHIMclassical monocyteshuman oral challengeintermediate monocytesnon-classical monocytesS. Typhi

Identifiers

PMID39263222
PMCPMC11388309

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.