Evidence map›Paper›PMID 39264244›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Mitochondrial tRNA

Lihao Jin, Dingyi Gan, Wentao He, Na Wu, Shuchenlu Xiang, Yinsheng Wei, Gilbert Eriani, Yanchun Ji, Min-Xin Guan, Meng Wang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Hypertensive mt. tRNARedox biology · 2026
    Article
  2. Review
  3. Review
  4. Mitochondrial tRNA-Derived Diseases.International journal of molecular sciences · 2025
    Review
  5. Mitochondrial tRNAAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lihao JinCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Dingyi GanCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Wentao HeCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Na WuCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Shuchenlu XiangCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Yinsheng WeiCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Gilbert ErianiArchitecture et Réactivité de l'ARN, UPR9002 Centre National de la Recherche Scientifique, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 2 allée Konrad Roentgen, Strasbourg, 67084, France.
Yanchun JiDivision of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou, 310058, China.
Min-Xin GuanCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Meng WangCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International institutes of Medicine, Zhejiang University, Yiwu, 322000, China.ORCID 0000-0001-6665-5884

Funding

Chinese National Science Foundation 82171847National Key Research and Development Program, Ministry of Science and Technology of China 2021YFC2700902National Key Research and Development Program, Ministry of Science and Technology of China 2021YFC2701901Young Top-notch Talents of Zhejiang Provincial High level Talents Special Support Plan 2021
6 · The paper itself

Abstract

Leber's hereditary optic neuropathy (LHON), a maternally inherited ocular disease, is predominantly caused by mitochondrial DNA (mtDNA) mutations. Mitochondrial tRNA variants are hypothesized to amplify the pathogenic impact of three primary mutations. However, the exact mechanisms remained unclear. In the present study, the synergistic effect of the tRNA

Indexed as

NADH DehydrogenaseOptic Atrophy, Hereditary, LeberRNA, MitochondrialRNA, Transfer, GluAge of OnsetApoptosisCell LineChildChild, PreschoolDNA Mutational AnalysisGenome, MitochondrialHumansMaleMitophagyMutationRNA StabilityMT-ND6 protein, humanNADH DehydrogenaseRNA, MitochondrialRNA, Transfer, Gluapoptosisleber's hereditary optic neuropathymitochondrial tRNA mutationmitophagyphenotypic expression

Identifiers

PMID39264244
PMCPMC11538713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.