Evidence map›Paper›PMID 39266290›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Molecular Imaging of p53 in Mouse Models of Cancer Using a Radiolabeled Antibody TAT Conjugate with SPECT.

Hudson Alakonya, Sofia Koustoulidou, Samantha L Hopkins, Mathew Veal, Javier Ajenjo, Deborah Sneddon, Gemma Dias, Michael Mosley, Julia Baguña Torres, Francesca Amoroso and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Development ofMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hudson AlakonyaDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Sofia KoustoulidouDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Samantha L HopkinsDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Mathew VealDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Javier AjenjoDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Deborah SneddonDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Gemma DiasDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Michael MosleyDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Julia Baguña TorresDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Francesca AmorosoDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Amanda AndersonNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; and.
Alison H BanhamNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; and.
Bart CornelissenDepartment of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom; bart.cornelissen@oncology.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations of p53 protein occur in over half of all cancers, with profound effects on tumor biology. We present the first-to our knowledge-method for noninvasive visualization of p53 in tumor tissue in vivo, using SPECT, in 3 different models of cancer.

Indexed as

Tomography, Emission-Computed, Single-PhotonTumor Suppressor Protein p53AnimalsAntibodies, MonoclonalCell Line, TumorDisease Models, AnimalGene Products, tatHumansImmunoconjugatesIndium RadioisotopesIsotope LabelingMiceMolecular ImagingAntibodies, MonoclonalGene Products, tatImmunoconjugatesIndium-111Indium RadioisotopesTumor Suppressor Protein p53cancermolecular imagingp53pancreatic ductal adenocarcinoma

Identifiers

PMID39266290
PMCPMC11448609

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.