Evidence map›Paper›PMID 39266447›Full record

ArticleGenes & development2024

Developmental regulation of dermal adipose tissue by BCL11b.

Sarah Traynor, Shashwati Bhattacharya, Kirill Batmanov, Lan Cheng, Angela Weller, Natalie Moore, Carmen Flesher, David Merrick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah TraynorDepartment of Medicine, Division of Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Shashwati BhattacharyaDepartment of Medicine, Division of Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Kirill BatmanovDepartment of Medicine, Division of Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Lan ChengInstitute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Angela WellerInstitute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Natalie MooreDepartment of Medicine, Division of Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Carmen FlesherDepartment of Medicine, Division of Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
David MerrickDepartment of Medicine, Division of Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; david.merrick@pennmedicine.upenn.edu.ORCID 0000-0001-6464-2705

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
Identification of a mesenchymal progenitor cell hierarchy in adipose tissueK08DK122099 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MERRICK, DAVID MICHAEL · 2019 to 2023
$840k
Developmental origins of dermal adipose tissueR56DK139097 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MERRICK, DAVID MICHAEL · 2025 to 2025
$122k
NIDDK NIH HHS K08 DK122099NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R56 DK139097
6 · The paper itself

Abstract

The distinct anatomic environment in which adipose tissues arise during organogenesis is a principle determinant of their adult expansion capacity. Metabolic disease results from a deficiency in hyperplastic adipose expansion within the dermal/subcutaneous depot; thus, understanding the embryonic origins of dermal adipose is imperative. Using single-cell transcriptomics throughout murine embryogenesis, we characterized cell populations, including

Indexed as

Gene Expression Regulation, DevelopmentalRepressor ProteinsAdipogenesisAdipose TissueAdipose Tissue, WhiteAnimalsCell DifferentiationHumansMiceTumor Suppressor ProteinsWnt Signaling PathwayBcl11b protein, mouseRepressor ProteinsTumor Suppressor Proteinsadipose developmentadipose lineageBcl11bdermal adiposeFAPNeflNgfrPi16single cell

Identifiers

PMID39266447
PMCPMC11444185

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.