ArticleNature communications2024
Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects.Nature genetics · 2026Article
- Association between thyroid peroxidase antibodies and rheumatoid arthritis: insights from genetic and population-based evidence.Clinical rheumatology · 2026Article
- Age- and Sex-Specific Reference Intervals for TSH, FT4, and FT3 Derived from the Turkish Multi-Center Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Rare coding and noncoding variants map 1,342 diseases and biomarkers in 490,549 whole genomes.medRxiv : the preprint server for health sciences · 2026Article
- Ambient Air Pollution, Preconceptional Thyrotropin Abnormalities, and the Risk of Preterm Birth: A Nationwide Chinese Cohort Study.Environment & health (Washington, D.C.) · 2026Article
- cfGWAS reveal genetic basis of cell-free DNA end motifs.Nature communications · 2026Article
- Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy.iScience · 2026Article
- Impact ofArchives of medical science : AMS · 2026Article
- Genetics of Thyroid Function: Relevance for Biology and Disease Management.The Journal of clinical endocrinology and metabolism · 2025Review
- Ambient biothermal stress, preconceptional thyrotropin abnormalities, and the risk of preterm birth: a nationwide Chinese cohort study.Nature communications · 2025Article
- Pregnancy-associated thyroid disorders: the role of genetic, epigenetic, and oxidative stress factors.Reviews in endocrine & metabolic disorders · 2025Review
- Utilizing non-invasive prenatal test sequencing data for human genetic investigation.Cell genomics · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
Maintaining normal thyroid function is crucial in pregnancy, yet thyroid dysfunction and the presence of thyroid peroxidase antibodies (TPOAb) affect 0.5% to 18% of pregnant women. Here, we conducted a genome-wide association study (GWAS) of eight thyroid traits, including two thyroid-related hormones, four thyroid dysfunctions, and two thyroid autoimmunity measurements among 85,421 Chinese pregnant women to investigate the genetic basis of thyroid function during pregnancy. Our study identified 176 genetic loci, including 125 previously unknown genome-wide associations. Joint epidemiological and Mendelian randomization analyses revealed significant associations between the gestational thyroid phenotypes and gestational complications, birth outcomes, and later-age health outcomes. Specifically, genetically elevated thyroid-stimulating hormone (TSH) levels during pregnancy correlated with lower glycemic levels, reduced blood pressure, and longer gestational duration. Additionally, TPOAb and thyroid functions during pregnancy share genetic correlations with later-age thyroid and cardiac disorders. These findings provide insights into the genetic determinants of thyroid traits during pregnancy, which may lead to new therapeutics, early pre-diagnosis and preventive strategies starting from early adulthood.
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