Evidence map›Paper›PMID 39266892›Full record

ReviewNeurogenetics2024

The role of gut-derived short-chain fatty acids in Parkinson's disease.

Mohamed J Saadh, Anfal Nabeel Mustafa, Mohammed Ahmed Mustafa, Renuka Jyothi S, Hasan Khalid Dabis, G V Siva Prasad, Imad Jassim Mohammad, Ahmed Adnan, Ameer Hassan Idan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurogenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohamed J SaadhFaculty of Pharmacy, Middle East University, Amman, 11831, Jordan. mohamedjsaadh@gmail.com.
Anfal Nabeel MustafaCollege of Pharmacy, Al-Noor University, Nineveh, Iraq.
Mohammed Ahmed MustafaSchool of Pharmacy-Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
Renuka Jyothi SDepartment of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
Hasan Khalid DabisAhl Al Bayt University, Kerbala, Iraq.
G V Siva PrasadDepartment of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra, Pradesh-531162, India.
Imad Jassim MohammadCollege of Health and Medical Technology, National University of Science and Technology, Dhi Qar, 64001, Iraq.
Ahmed AdnanMedical Technical College, Al-Farahidi University, Baghdad, Iraq.
Ameer Hassan IdanAl-Zahrawi University College, Karbala, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emerging function of short-chain fatty acids (SCFAs) in Parkinson's disease (PD) has been investigated in this article. SCFAs, which are generated via the fermentation of dietary fiber by gut microbiota, have been associated with dysfunction of the gut-brain axis and, neuroinflammation. These processes are integral to the development of PD. This article examines the potential therapeutic implications of SCFAs in the management of PD, encompassing their capacity to modulate gastrointestinal permeability, neuroinflammation, and neuronal survival, by conducting an extensive literature review. As a whole, this article emphasizes the potential therapeutic utility of SCFAs as targets for the management and treatment of PD.

Indexed as

Brain-Gut AxisFatty Acids, VolatileGastrointestinal MicrobiomeParkinson DiseaseAnimalsDietary FiberHumansDietary FiberFatty Acids, VolatileNeurodegenerationNeuroprotectionParkinson's diseaseShort-chain fatty acids

Identifiers

PMID39266892

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.