Evidence map›Paper›PMID 39267514›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[Effects of inhibition of Rho/ROCK pathway on proliferation and migration of airway smooth muscle cells and related mechanisms].

Yun-Fei Cui, Qing-Hua Lu, Xiao Huang, Wei-Nan Lin, Ting Huang, Qin Yang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yun-Fei CuiDepartment of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518036, China.
Qing-Hua LuDepartment of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518036, China.
Xiao HuangDepartment of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518036, China.
Wei-Nan LinDepartment of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518036, China.
Ting HuangDepartment of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518036, China.
Qin YangDepartment of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong 518036, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effects and molecular mechanisms of inhibition of the Ras homolog gene (Rho)/Rho-associated coiled-coil forming protein kinase (ROCK) pathway on the proliferation and migration of airway smooth muscle cells involving myocardin (MYOCD).

methodsHuman airway smooth muscle cells were infected with the adenoviral vector Ad-ZsGreen-shRNA-hROCK1

resultsCompared to the shNC + AA group, the shROCK1 + AA group exhibited decreased levels of ROCK1 and MYOCD mRNA and protein expression, reduced expression levels of globular actin and filamentous actin, and diminished cell proliferation and migration capabilities (

conclusionsInhibition of the Rho/ROCK pathway suppresses the proliferation and migration of airway smooth muscle cells, which may be associated with the downregulation of MYOCD.

Indexed as

Cell MovementCell ProliferationMyocytes, Smooth Musclerho-Associated KinasesSignal TransductionTrans-ActivatorsCells, CulturedHumansMyocardinNuclear Proteinsrho GTP-Binding ProteinsMyocardinNuclear Proteinsrho-Associated Kinasesrho GTP-Binding ProteinsROCK1 protein, humanTrans-ActivatorsAirway smooth muscle cellAsthmaMyocardinProliferationRho/ROCK pathway

Identifiers

PMID39267514
PMCPMC11404462

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.