Evidence map›Paper›PMID 39267666›Full record

ArticleAmerican journal of cancer research2024

Cucurbitacin E elicits apoptosis in laryngeal squamous cell carcinoma by enhancing reactive oxygen species-regulated mitochondrial dysfunction and endoplasmic reticulum stress.

Xucai Zheng, Puze Tang, Hui Li, Tingbo Ye, Xu Zhu, Wei He, Ling Cheng, Huaidong Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xucai ZhengDepartment of Oncology, The Second Hospital of Anhui Medical University Hefei 230601, Anhui, China.
Puze TangBachelor of Science in Mathematics, University of Liverpool United Kingdom.
Hui LiDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical University Hefei 230032, Anhui, China.
Tingbo YeDepartment of Head, Neck and Breast Surgery, The First Affiliated Hospital of USTC, Anhui Provincial Cancer Hospital Hefei 230031, Anhui, China.
Xu ZhuDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical University Hefei 230032, Anhui, China.
Wei HeDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical University Hefei 230032, Anhui, China.
Ling ChengMedical Intensive Care Unit, The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei 230031, Anhui, China.
Huaidong ChengDepartment of Oncology, The Second Hospital of Anhui Medical University Hefei 230601, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laryngeal squamous cell carcinoma (LSCC) is a prevalent head and neck neoplasm with escalating global morbidity and mortality rates. Despite the increasing burden of LSCC, the drugs currently approved for its treatment are limited. Therefore, it is necessary to identify novel and promising drugs that target LSCC. Cucurbitacin E (CuE) is a naturally oxygenated tetracyclic triterpenoid that suppresses several cancers. However, its anti-LSCC activity and the molecular mechanisms of action remain unclear. This study explored its impact on LSCC, revealing cell viability attenuation and apoptosis enhancement

Indexed as

Cucurbitacin Eendoplasmic reticulum stresslaryngeal squamous cell carcinomamitochondrial dysfunctionreactive oxygen species

Identifiers

PMID39267666
PMCPMC11387858

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.