Evidence map›Paper›PMID 39267884›Full record

ArticleGlobal pediatrics2024

Hepatic mitochondrial and peroxisomal alterations in acutely ill malnourished Malawian children: A postmortem cohort study.

Catriona M Ling, Tewabu F Sheferaw, Donna M Denno, Dennis Chasweka, Steve B Kamiza, Jaume Ordi, Christopher A Moxon, Kim Kats, Stanley Khoswe, Emmie Mbale and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Catriona M LingDepartment of Nutritional Sciences, University of Toronto, Toronto, Canada.
Tewabu F SheferawAmsterdam UMC location University of Amsterdam, Amsterdam Centre for Global Child Health, Emma Children's hospital, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
Donna M DennoDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Dennis ChaswekaThe Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
Steve B KamizaDepartment of Pathology, Kumuzu University of Health Sciences, Blantyre, Malawi.
Jaume OrdiDepartment of Pathology, Hospital Clinic, Universitat de Barcelona, Spain.
Christopher A MoxonDepartment of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Kim KatsDepartment of Biomedical Science of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Stanley KhosweMalawi-Liverpool Wellcome Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
Emmie MbaleThe Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
Frank ZiwoyaThe Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
Abel TemboThe Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
Charalampos AttipaDepartment of Pathology, Kumuzu University of Health Sciences, Blantyre, Malawi.
Isabel PotaniDepartment of Nutritional Sciences, University of Toronto, Toronto, Canada.
Peter K KimDepartment of Biochemsitry, University of Toronto, Toronto, ON, Canada.
James A BerkleyThe Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
Judd L WalsonThe Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
Wieger P VoskuijlAmsterdam UMC location University of Amsterdam, Amsterdam Centre for Global Child Health, Emma Children's hospital, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
Robert H J BandsmaDepartment of Nutritional Sciences, University of Toronto, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To describe and compare liver mitochondrial and peroxisomal histopathology by nutritional status in children who died following hospitalization for acute illness in Malawi. Methods: Liver tissue was collected using Minimally Invasive Tissue Sampling from eleven children under-five years old who died during hospitalization and were either non-wasted ( Results: Hepatic steatosis was present in 50 % of non-wasted and severely wasted children and all children with edematous malnutrition. Edematous malnutrition was associated with 56 % and 45 % fewer mitochondria than severe wasting ( Conclusion: Edematous malnutrition is associated with reduced abundance and altered morphology of hepatic mitochondria and peroxisomes. Interventions targeting improvements in hepatic metabolic function may be beneficial in improving metabolism and reducing mortality in children with severe malnutrition, particularly in those with nutritional edema.

Indexed as

Edematous malnutritionKwashiorkorLiverMarasmusMinimally invasive tissue samplingMitochondriaPeroxisomesSevere malnutritionSevere wastingSteatosis

Identifiers

PMID39267884
PMCPMC11387285

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.