Evidence map›Paper›PMID 39269553›Full record

ArticleBreast cancer research and treatment2025

Characterizing cancer-related cognitive impairments and impact on quality of life in women with metastatic breast cancer.

Ashley M Henneghan, Kathleen M Van Dyk, Darren Haywood, Mansi Patel, Oscar Y Franco-Rocha, Soyeong Bang, Tamsin Longley, Rebecca Tasker, Tara Kaufmann, Emily W Paolillo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Accounting for unmet needs resulting from cancer-related cognitive impairment.Journal of cancer survivorship : research and practice · 2026
    Article
  4. Article
  5. The MASCC COG-IMPACT: An unmet needs assessment for cancer-related cognitive impairment impact developed by the Multinational Association of Supportive Care in Cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ashley M HenneghanSchool of Nursing, University of Texas at Austin, Austin, TX, USA. ahenneghan@nursing.utexas.edu.
Kathleen M Van DykSemel Institute of Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Darren HaywoodFaculty of Health, Human Performance Research Centre, INSIGHT Research Institute, , University of Technology Sydney (UTS), Sydney, NSW, Australia.
Mansi PatelDepartment of Neuroscience, College of Natural Sciences, University of Texas at Austin, Austin, TX, USA.
Oscar Y Franco-RochaSchool of Nursing, University of Texas at Austin, Austin, TX, USA.
Soyeong BangSchool of Nursing, Columbia University, New York, NY, USA.
Tamsin LongleyThe Royal Marsden Hospital, London, UK.
Rebecca TaskerSchool of Nursing, University of Texas at Austin, Austin, TX, USA.
Tara KaufmannDell Medical School, University of Texas at Austin, Austin, TX, USA.
Emily W PaolilloDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Raeanne C MooreUC San Diego Health Sciences, University of California San Diego, San Diego, CA, USA.
Nicolas H HartFaculty of Health, Human Performance Research Centre, INSIGHT Research Institute, , University of Technology Sydney (UTS), Sydney, NSW, Australia.

Funding

Social Determinants of Health as Transducers of Cellular Aging: A New Multi-level Paradigm to Reduce Survivorship Disparities at the Intersection of Cancer and AgingR35CA283926 · NCI · GEORGETOWN UNIVERSITY · PI Jeanne Mandelblatt · 2023 to 2026
$3.7M
Brain Health in Breast Cancer Survivors: Interaction of Menopause and Endocrine TherapyK08CA241337 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DYK, KATHLEEN · 2019 to 2023
$925k
Defining Cognitive Patient Reported Outcomes of Breast Cancer Survivors in the Context of Everyday Functioning and Quality of LifeR21NR020497 · NINR · UNIVERSITY OF TEXAS AT AUSTIN · PI HENNEGHAN, ASHLEY M. · 2023 to 2024
$447k
American Cancer Society CSDG-23-1019130-01-CTPSAmerican Cancer Society IRG-21-135-01-IRGNational Health and Medical Research Council APP2018070NCI NIH HHS K08 CA241337NCI NIH HHS K08CA241337NCI NIH HHS R35 CA283926NINR NIH HHS R21 NR020497NINR NIH HHS R21NR020497
6 · The paper itself

Abstract

purposeLittle is known about cancer-related cognitive impairments (CRCI) in women with metastatic breast cancer (MBC). The purpose of this study is to (1) comprehensively describe CRCI and any associated psychosocial and behavioral symptoms, (2) determine observable sociodemographic and clinical risk factors for CRCI, and (3) explore cognitive and psychosocial predictors of quality of life and social functioning in women living with MBC.

methodsUsing a cross-sectional design, women with MBC completed assessments (objective and subjective measures of CRCI including 3 open-ended questions, measures of psychosocial and behavioral factors, and assessments of quality of life and social function), and data were analyzed using descriptive statistics, qualitative content analysis, correlation analyses, t tests, analysis of variance, and linear regression models.

resultsData from 52 women were analyzed. 69.2% of the sample reported clinically significant CRCI and 46% of the sample scored < 1 standard deviation below the standardized mean on one or more cognitive tests. Those with triple-negative MBC (compared to HER2+), recurrent MBC (compared to de novo), and no history of chemotherapy had worse subjective CRCI, and those without history of surgery and older age had worse objective CRCI. Subjective CRCI, but not objective CRCI, was significantly associated with quality of life and social functioning.

conclusionSubjective and objective CRCI are likely a common problem for those with MBC. Subjective CRCI is associated with poorer quality of life and lower social functioning. Healthcare providers should acknowledge cognitive symptoms, continually assess cognitive function, and address associated unmet needs across the MBC trajectory.

Indexed as

Breast NeoplasmsCognitive DysfunctionQuality of LifeAdultAgedCross-Sectional StudiesFemaleHumansMiddle AgedNeoplasm MetastasisRisk FactorsCancer-related cognitive impairmentsClinically meaningful thresholdsMetastatic breast cancerQuality of lifeSocial function

Identifiers

PMID39269553
PMCPMC12308896

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.