ArticleScience advances2024
Evaluating the distinct effects of body mass index at childhood and adulthood on adult major psychiatric disorders.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Are There Causal Associations Between Obsessive-Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi-Directional Mendelian Randomization Study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Clinical and sociodemographic correlates of body mass index in a large multicenter obsessive-compulsive disorder sample.Eating and weight disorders : EWD · 2026Article
- Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Molecular psychiatry · 2026Review
- Genetic susceptibility to depression and risk of cardiometabolic diseases: a systematic review and meta-analysis of 21 Mendelian randomisation studies.EClinicalMedicine · 2025Article
- The rapid growth in Mendelian randomization studies.European journal of epidemiology · 2025Article
- Relationship between blood-cerebrospinal fluid barrier integrity, cardiometabolic, and inflammatory factors in schizophrenia-spectrum disorders.Brain, behavior, & immunity - health · 2025Article
- Relationship Between Family Support, C-Reactive Protein and Body Mass Index Among Outpatients with Schizophrenia.Healthcare (Basel, Switzerland) · 2025Article
- Identification of the Critical Life-Stage of Obesity Contributing to Brain Functional Networks.CNS neuroscience & therapeutics · 2025Article
- Correlation between lifestyle choices, dietary factors, and the risk of adult urolithiasis: insights from a systematic review and meta-analysis.Translational andrology and urology · 2025Article
- Evaluating the causal effects of life-course adiposity on jaw anomalies.Progress in orthodontics · 2025Article
- Relationship between BMI, indicators of lipid metabolism and diabetic neuropathy: a Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with high body mass index (BMI) are at heightened risk of developing health issues in adulthood, yet the causality between childhood BMI and adult psychiatric disorders remains unclear. Using a life course Mendelian randomization (MR) framework, we investigated the causal effects of childhood and adulthood BMI on adult psychiatric disorders, including Alzheimer's disease, anxiety, major depressive disorder, obsessive-compulsive disorder (OCD), and schizophrenia, using data from the Psychiatric Genomics Consortium and FinnGen study. Childhood BMI was significantly associated with an increased risk of schizophrenia, while adulthood BMI was associated with a decreased risk of OCD and schizophrenia. Multivariable MR analyses indicated a direct causal effect of childhood BMI on schizophrenia, independent of adulthood BMI and lifestyle factors. No evidence of causal associations was found between childhood BMI and other psychiatric outcomes. The sensitivity analyses yielded broadly consistent findings. These findings highlight the critical importance of early-life interventions to mitigate the long-term consequences of childhood adiposity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.