Evidence map›Paper›PMID 39272114›Full record

Trial reportBMC women's health2024

A 2-year follow-up to a randomized controlled trial on resistance training in postmenopausal women: vasomotor symptoms, quality of life and cardiovascular risk markers.

Sigrid Nilsson, Moa Henriksson, Mats Hammar, Emilia Berin, Sofia Sederholm Lawesson, Liam J Ward, Wei Li, Anna-Clara Spetz Holm

Registry-linked trialAbstract readRandomized Controlled TrialObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01987778 (Health Effects of Resistance Training on Postmenopausal Women), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01987778 nacompletednot on this map

Health Effects of Resistance Training on Postmenopausal Women

TypeinterventionalSponsorOstergotland County Council, SwedenRan2013 to 2020Enrolled65ConditionsHot Flashes, MenopauseArmsResistance training
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sigrid NilssonDepartment of Obstetrics and Gynecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, 58185, Linköping, Sweden. sigrid.nilsson@liu.se.
Moa HenrikssonDepartment of Obstetrics and Gynecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, 58185, Linköping, Sweden.
Mats HammarDepartment of Obstetrics and Gynecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, 58185, Linköping, Sweden.
Emilia BerinDepartment of Obstetrics and Gynecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, 58185, Linköping, Sweden.
Sofia Sederholm LawessonDepartment of Cardiology, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Liam J WardDepartment of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping University, Linköping, Sweden.
Wei LiDepartment of Obstetrics and Gynecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, 58185, Linköping, Sweden.
Anna-Clara Spetz HolmDepartment of Obstetrics and Gynecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, 58185, Linköping, Sweden.

Funding

Vetenskapsrådet 2014-2781
6 · The paper itself

Abstract

backgroundMost women experience vasomotor symptoms (VMS) during the menopausal transition. A 15-week resistance training intervention (RTI) significantly reduced moderate-to-severe VMS (MS-VMS) and improved health-related quality of life (HRQoL) and cardiovascular risk markers in postmenopausal women. Whether a short RTI could have long-term effects is unknown. We aimed to investigate whether there were intervention-dependent effects two years after a 15-week RTI on MS-VMS frequency, HRQoL, and cardiovascular risk markers in postmenopausal women.

methodsThis observational prospective cohort study is a follow-up to a randomized controlled trial (RCT) on a 15-week RTI in postmenopausal women (n = 57). The control group had unchanged low physical activity during these first 15 weeks. At the follow-up contact two years post-intervention, 35 women agreed to participate in an additional physical visit at the clinic with clinical testing, blood sampling, and magnetic resonance imaging, identical to the protocol at the baseline visit at the start of the RCT.

resultsAlthough all women showed reduced MS-VMS and increased moderate-to-vigorous physical activity (MVPA) over the 2-year follow-up compared to baseline, the groups from the original RCT (intervention group; IG, control group; CG) changed differently over time (p < 0.001 and p = 0.006, respectively) regarding MS-VMS. The IG maintained a significantly lower MS-VMS frequency than the CG at the 6-month follow-up. At the 2-year follow-up, there was no significant difference between the original RCT groups. No significant changes over time or differences between groups were found in HRQoL or cardiovascular risk markers. However, significant interactions between original RCT groups and time were found for visceral adipose tissue (p = 0.041), ferritin (p = 0.045), and testosterone (p = 0.010).

conclusionsA 15-week resistance training intervention reduced MS-VMS frequency up to six months post-intervention compared to a CG, but the effect was not maintained after two years. The RTI did neither contribute to preserved improvements of cardiovascular risk markers nor improved HRQoL after two years compared to a CG.

trial registrationClinical trials.gov registered ID: NCT01987778, trial registration date 2013-11-19.

Indexed as

Cardiovascular DiseasesPostmenopauseQuality of LifeResistance TrainingBiomarkersExerciseFemaleFollow-Up StudiesHeart Disease Risk FactorsHot FlashesHumansMiddle AgedProspective StudiesVasomotor SystemBiomarkersCardiovascular risk markersFollow-upHealth-related quality of lifeHot flushesMenopauseMidlifePhysical activityVasomotor symptoms

Identifiers

PMID39272114
PMCPMC11396825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.