Evidence map›Paper›PMID 39272790›Full record

ReviewCancers2024

Updates on Therapeutic Strategies in the Treatment of Relapsed/Refractory Multiple Myeloma.

Deevyashali S Parekh, Yun Kyoung Ryu Tiger, Kevin Tony Jamouss, Justin Hassani, Maroun Bou Zerdan, Shahzad Raza

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deevyashali S ParekhDepartment of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Yun Kyoung Ryu TigerRutgers Cancer Institute, New Brunswick, NJ 08901, USA.
Kevin Tony JamoussUniversity of Massachusetts Chan Medical School, Baystate Campus, Springfield, MA 01107, USA.ORCID 0000-0001-5039-6013
Justin HassaniUniversity of Massachusetts Chan Medical School, Baystate Campus, Springfield, MA 01107, USA.
Maroun Bou ZerdanDepartment of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Shahzad RazaDepartment of Hematology and Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-2739-2265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma is a heterogeneous condition characterized by the proliferation of monoclonal B-cells, for which there is currently no curative treatment available. Relapses are, unfortunately, common after first-line treatment. While the prognosis for relapsed refractory multiple myeloma is generally poor, advances in the treatment of relapsed or refractory multiple myeloma offer hope. However, the expansion of effective options in targeted treatment offers renewed optimism and hope that patients who fail on older therapies may respond to newer modalities, which are often used in combination. We review currently approved and novel investigational agents classified by mechanisms of action, efficacy, approved setting, and adverse events. We delve into future directions of treatment for relapsed/refractory multiple myeloma, reviewing novel agents and therapeutic targets for the future.

Indexed as

bispecific antibodiesCAR-Tcelmodsmonoclonal antibodiesmultiple myelomaproteasome inhibitorsrelapsed refractory

Identifiers

PMID39272790
PMCPMC11394453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.