Evidence map›Paper›PMID 39272842›Full record

ArticleCancers2024

Using mHealth Technology to Evaluate Daily Symptom Burden among Adult Survivors of Childhood Cancer: A Feasibility Study.

Kristen E Howell, Jessica L Baedke, Farideh Bagherzadeh, Aaron McDonald, Paul C Nathan, Kirsten K Ness, Melissa M Hudson, Gregory T Armstrong, Yutaka Yasui, I-Chan Huang

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristen E HowellDepartment of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-5227-5941
Jessica L BaedkeSchool of Public Health, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0001-5085-4985
Farideh BagherzadehSchool of Public Health, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Aaron McDonaldDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Paul C NathanDivision of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.ORCID 0000-0003-0334-0871
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Melissa M HudsonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-6984-2407
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yutaka YasuiDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-7717-8638
I-Chan HuangDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-1194-3923

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Markos Leggas · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
The St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9M
Patient-Generated Health Data to Predict Childhood Cancer Survivorship OutcomesR01CA258193 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI I-Chan Huang, YUTAKA YASUI · 2021 to 2026
$3.7M
Patient-Reported Outcomes Version of CTCAE involving Childhood Cancer SurvivorsR01CA238368 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, JUSTIN N, HUANG, I-CHAN · 2019 to 2023
$3.5M
NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA238368NCI NIH HHS R01 CA258193NCI NIH HHS U01 CA195547NCI NIH HHS U24 CA055727U.S. National Cancer Institute U01CA195547, U24CA055727, R01CA258193, R01CA238368, P30CA021765
6 · The paper itself

Abstract

backgroundCancer therapies predispose survivors to a high symptom burden. This study utilized mobile health (mHealth) technology to assess the feasibility of collecting daily symptoms from adult survivors of childhood cancer to evaluate symptom fluctuation and associations with future health-related quality-of-life (HRQOL).

methodsThis prospective study used an mHealth platform to distribute a 20-item cancer-related symptom survey (5 consecutive days each month) and an HRQOL survey (the day after the symptom survey) over 3 consecutive months to participants from the Childhood Cancer Survivor Study. These surveys comprised a PROMIS-29 Profile and Neuro-QOL assessed HRQOL. Daily symptom burden was calculated by summing the severity (mild, moderate, or severe) of 20 symptoms. Univariate linear mixed-effects models were used to analyze total, person-to-person, day-to-day, and month-to-month variability for the burden of 20 individual symptoms. Multivariable linear regression was used to analyze the association between daily symptom burden in the first month and HRQOL in the third month, adjusted for covariates.

resultsOut of the 60 survivors invited, 41 participated in this study (68% enrollment rate); 83% reported their symptoms ≥3 times and 95% reported HRQOL in each study week across 3 months. Variability of daily symptom burden differed from person-to-person (74%), day-to-day (18%), and month-to-month (8%). Higher first-month symptom burden was associated with poorer HRQOL related to anxiety (regression coefficient: 6.56; 95% CI: 4.10-9.02), depression (6.32; 95% CI: 3.18-9.47), fatigue (7.93; 95% CI: 5.11-10.80), sleep (6.07; 95% CI: 3.43-8.70), pain (5.16; 95% CI: 2.11-8.22), and cognitive function (-6.89; 95% CI: -10.00 to -3.79) in the third month.

conclusionsDaily assessment revealed fluctuations in symptomology, and higher symptom burden was associated with poorer HRQOL in the future. Utilizing mHealth technology for daily symptom assessment improves our understanding of symptom dynamics and sources of variability.

Indexed as

childhood cancer survivorshealth-related quality of lifemHealthmomentary assessmentsymptoms

Identifiers

PMID39272842
PMCPMC11394214

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.