Evidence map›Paper›PMID 39273106›Full record

ArticleInternational journal of molecular sciences2024

BMP4-Induced Suppression of Breast Cancer Metastasis Is Associated with Inhibition of Cholesterol Biosynthesis.

Lap Hing Chi, Andrew D Redfern, Terry C C Lim Kam Sian, Ian P Street, Allan D Burrows, Suraya Roslan, Roger J Daly, Robin L Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lap Hing ChiOlivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.ORCID 0000-0003-0983-3474
Andrew D RedfernMedical School, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-6728-8713
Terry C C Lim Kam SianCancer Program, Monash Biomedicine Discovery Institute, Clayton, VIC 3168, Australia.ORCID 0000-0001-7038-1214
Ian P StreetChildren's Cancer Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Allan D BurrowsOlivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.ORCID 0000-0003-0595-1414
Suraya RoslanDepartment of Surgery, St. Vincent's Hospital, Fitzroy, VIC 3065, Australia.
Roger J DalyCancer Program, Monash Biomedicine Discovery Institute, Clayton, VIC 3168, Australia.ORCID 0000-0002-5739-8027
Robin L AndersonOlivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.ORCID 0000-0002-6841-7422

Funding

Cancer Council Victoria APP1006425National Health & Medical Research Council APP1121199Wellcome Trust UNS16464
6 · The paper itself

Abstract

We reported previously that in preclinical models, BMP4 is a potent inhibitor of breast cancer metastasis and that high BMP4 protein levels predict favourable patient outcomes. Here, we analysed a breast cancer xenograft with or without enforced expression of BMP4 to gain insight into the mechanisms by which BMP4 suppresses metastasis. Transcriptomic analysis of cancer cells recovered from primary tumours and phosphoproteomic analyses of cancer cells exposed to recombinant BMP4 revealed that BMP4 inhibits cholesterol biosynthesis, with many genes in this biosynthetic pathway being downregulated by BMP4. The treatment of mice bearing low-BMP4 xenografts with a cholesterol-lowering statin partially mimicked the anti-metastatic activity of BMP4. Analysis of a cohort of primary breast cancers revealed a reduced relapse rate for patients on statin therapy if their tumours exhibited low BMP4 levels. These findings indicate that BMP4 may represent a predictive biomarker for the benefit of additional statin therapy in breast cancer patients.

Indexed as

Bone Morphogenetic Protein 4Breast NeoplasmsCholesterolAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMiceNeoplasm MetastasisXenograft Model Antitumor AssaysBMP4 protein, humanBone Morphogenetic Protein 4CholesterolHydroxymethylglutaryl-CoA Reductase InhibitorsBMP4breast cancercholesterol biosynthesismetastasisstatins

Identifiers

PMID39273106
PMCPMC11395556

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.