Evidence map›Paper›PMID 39273153›Full record

ArticleInternational journal of molecular sciences2024

Intrapulmonary T Cells Are Sufficient for

Dara C Fonseca Balladares, Biruk Kassa, Claudia Mickael, Rahul Kumar, Kevin Nolan, Thais C F Menezes, Michael H Lee, Anthony M Lau-Xiao, Ari B Molofsky, Elina Wells and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pulmonary Immune Cell Landscape Altered by Exposure to HIV,International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dara C Fonseca BalladaresLung Biology Center, Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA.
Biruk KassaLung Biology Center, Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA.
Claudia MickaelProgram in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-1064-311X
Rahul KumarLung Biology Center, Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA.
Kevin NolanLung Biology Center, Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA.
Thais C F MenezesDivision of Respiratory Diseases, Department of Medicine, Federal University of São Paulo, São Paulo 04021-001, SP, Brazil.
Michael H LeeLung Biology Center, Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-5739-8369
Anthony M Lau-XiaoLung Biology Center, Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA.
Ari B MolofskyDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-0764-3175
Elina WellsDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Brian B GrahamLung Biology Center, Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0001-7541-2585

Funding

Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DELANEY, CASSIDY A · 2020 to 2024
$14.1M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
The contribution of hypoxia inducible factor-1-dependent glycolysis in lung interstitial macrophages to the pathobiology of schistosomiasis-induced pulmonary hypertension.K08HL168310 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michael Hyunjean Lee · 2023 to 2026
$676k
Novel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary HypertensionK01HL161024 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Claudia Silva Mickael · 2022 to 2026
$661k
NHLBI NIH HHS K01 HL161024NHLBI NIH HHS K08 HL168310NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R01 HL135872NIH HHS 3R01HL135872-07S1
6 · The paper itself

Abstract

backgroundSchistosomiasis is a parasitic infection that can cause pulmonary hypertension (PH). Th2 CD4 T cells are necessary for experimental

methodsMice were sensitized to

resultsFTY720 decreased T cells in the peripheral blood, and increased T cells in the mediastinal lymph nodes. However, FTY720 treatment resulted in no change in PH or type 2 inflammation severity in mice sensitized and challenged with

conclusionBlocking T cell migration did not suppress PH following

Indexed as

Hypertension, PulmonaryLungSchistosoma mansoniAnimalsCD4-Positive T-LymphocytesCytokinesDisease Models, AnimalFemaleFingolimod HydrochlorideInterleukin-4MiceMice, Inbred C57BLSchistosomiasisSchistosomiasis mansoniTh2 CellsT-LymphocytesCytokinesFingolimod HydrochlorideInterleukin-4CD4 T cellsFTY720pulmonary hypertensionschistosomiasis

Identifiers

PMID39273153
PMCPMC11395458

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.