Evidence mapPaperPMID 39273274Full record

ArticleInternational journal of molecular sciences2024

Transcriptomic Module Discovery of Diarrhea-Predominant Irritable Bowel Syndrome: A Causal Network Inference Approach.

Davide Guido, Fatima Maqoud, Michelangelo Aloisio, Domenica Mallardi, Blendi Ura, Nicolò Gualandi, Massimiliano Cocca, Francesco Russo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Davide GuidoData Science Unit, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Bari, Italy.
Fatima MaqoudFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Bari, Italy.
Michelangelo AloisioFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Bari, Italy.
Domenica MallardiFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Bari, Italy.ORCID 0000-0002-0629-0972
Blendi UraInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Nicolò GualandiDepartment of Medicine, Laboratory of Biochemistry, University of Udine, P.le Kolbe 4, 33100 Udine, Italy.ORCID 0000-0003-0622-6118
Massimiliano CoccaINSERM U1052, CNRS UMR_5286, Cancer Research Center of Lyon (CRCL), 69008 Lyon, France.ORCID 0000-0002-1127-7596
Francesco RussoFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Bari, Italy.ORCID 0000-0003-0538-6072

Funding

Italian Ministry of Health RC 2022-2024, Prog. N. 19 (DDG_661_23.12.2022)
6 · The paper itself

Abstract

Irritable bowel syndrome with diarrhea (IBS-D) is the most prevalent subtype of IBS, characterized by chronic gastrointestinal symptoms in the absence of identifiable pathological findings. This study aims to investigate the molecular mechanisms underlying IBS-D using transcriptomic data. By employing causal network inference methods, we identify key transcriptomic modules associated with IBS-D. Utilizing data from public databases and applying advanced computational techniques, we uncover potential biomarkers and therapeutic targets. Our analysis reveals significant molecular alterations that affect cellular functions, offering new insights into the complex pathophysiology of IBS-D. These findings enhance our understanding of the disease and may foster the development of more effective treatments.

Indexed as

DiarrheaGene Regulatory NetworksIrritable Bowel SyndromeTranscriptomeBiomarkersComputational BiologyGene Expression ProfilingHumansBiomarkersbiomarkerscausal network inferenceIBS-Dtherapeutic targetstranscriptomics

Identifiers

PMID39273274
PMCPMC11394741

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.