Evidence map›Paper›PMID 39273308›Full record

ArticleInternational journal of molecular sciences2024

MicroRNA Profiling in Papillary Thyroid Cancer.

Richard Armos, Bence Bojtor, Marton Papp, Ildiko Illyes, Balazs Lengyel, Andras Kiss, Balazs Szili, Balint Tobias, Bernadett Balla, Henriett Piko and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Richard ArmosDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.ORCID 0009-0005-3334-1308
Bence BojtorDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.ORCID 0009-0004-5018-751X
Marton PappCentre for Bioinformatics, University of Veterinary Medicine, 1078 Budapest, Hungary.
Ildiko IllyesDepartment of Pathology, Forensic and Insurance Medicine, Faculty of Medicine, Semmelweis University, 1091 Budapest, Hungary.
Balazs LengyelDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Andras KissDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Balazs SziliDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0002-2816-9487
Balint TobiasDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0003-4343-1866
Bernadett BallaSE HUN-REN-TKI ENDOMOLPAT Research Group, 1085 Budapest, Hungary.
Henriett PikoDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Anett IllesDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0001-5351-9015
Zsuzsanna PutzDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Andras KissDepartment of Pathology, Forensic and Insurance Medicine, Faculty of Medicine, Semmelweis University, 1091 Budapest, Hungary.ORCID 0000-0002-7453-3163
Erika TothDepartment of Surgical and Molecular Pathology, National Institute of Oncology, 1122 Budapest, Hungary.ORCID 0000-0003-2054-8447
Istvan TakacsDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Janos P KosaDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.
Peter LakatosDepartment of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1083 Budapest, Hungary.

Funding

Hungarian Research Network SE HUN-REN-TKI ENDOMOLPATMinistry for Innovation and Technology 2020-4.1.1.-TKP2020-MOLORKIVNational Research, Development and Innovation Office OTKA K128780
6 · The paper itself

Abstract

Genetic alterations are well known to be related to the pathogenesis and prognosis of papillary thyroid carcinoma (PTC). Some miRNA expression dysregulations have previously been described in the context of cancer development including thyroid carcinoma. In our study, we performed original molecular diagnostics on tissue samples related to our own patients. We aimed to identify all dysregulated miRNAs in potential association with PTC development via sequencing much higher numbers of control-matched PTC tissue samples and analyzing a wider variety of miRNA types than previous studies. We analyzed the expression levels of 2656 different human miRNAs in the context of 236 thyroid tissue samples (118 tumor and control pairs) related to anonymized PTC cases. Also, KEGG pathway enrichment analysis and GO framework analysis were used to establish the links between miRNA dysregulation and certain biological processes, pathways of signaling, molecular functions, and cellular components. A total of 30 significant differential miRNA expressions with at least ±1 log

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticMicroRNAsThyroid Cancer, PapillaryThyroid NeoplasmsAdultBiomarkers, TumorCarcinoma, PapillaryFemaleGene Regulatory NetworksHumansMaleMiddle AgedSignal TransductionBiomarkers, TumorMicroRNAsmiRNAmiRNA patternmolecular diagnosticspapillary thyroid carcinomasequencingthyroid cancer

Identifiers

PMID39273308
PMCPMC11395536

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.