Evidence map›Paper›PMID 39273333›Full record

ArticleInternational journal of molecular sciences2024

The Bifunctional Dimer Caffeine-Indan Attenuates α-Synuclein Misfolding, Neurodegeneration and Behavioral Deficits after Chronic Stimulation of Adenosine A1 Receptors.

Elisabet Jakova, Omozojie P Aigbogun, Mohamed Taha Moutaoufik, Kevin J H Allen, Omer Munir, Devin Brown, Changiz Taghibiglou, Mohan Babu, Chris P Phenix, Ed S Krol and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elisabet JakovaDepartment of Surgery, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Omozojie P AigbogunDepartment of Chemistry, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada.ORCID 0000-0002-7655-665X
Mohamed Taha MoutaoufikDepartment of Chemistry and Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.ORCID 0000-0002-2013-1601
Kevin J H AllenPharmaceutical and Nutrition Sciences Research Group, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Omer MunirDepartment of Anatomy, Physiology, Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Devin BrownDepartment of Chemistry, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada.
Changiz TaghibiglouDepartment of Anatomy, Physiology, Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.ORCID 0000-0002-4527-7404
Mohan BabuDepartment of Chemistry and Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.
Chris P PhenixDepartment of Chemistry, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada.ORCID 0000-0001-8392-5268
Ed S KrolCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Francisco S CayabyabDepartment of Surgery, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.ORCID 0000-0002-5058-7087

Funding

Natural Sciences and Engineering Research Council Discovery Grant RGPIN-2015-03850
6 · The paper itself

Abstract

We previously found that chronic adenosine A1 receptor stimulation with N

Indexed as

alpha-SynucleinCaffeineReceptor, Adenosine A1AnimalsBehavior, AnimalMaleMolecular Docking SimulationNeuroprotective AgentsParkinson DiseasePositron-Emission TomographyProtein FoldingRatsalpha-SynucleinCaffeineNeuroprotective AgentsReceptor, Adenosine A11-aminoindanadenosine A1 receptorbiodistributioncaffeinedimerN6-cyclopentyladenosineneuroprotectionPET-imagingprotein misfoldingα-synucleinopathy

Identifiers

PMID39273333
PMCPMC11395333

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.