Evidence map›Paper›PMID 39273372›Full record

ArticleInternational journal of molecular sciences2024

Specific microRNA Profile Associated with Inflammation and Lipid Metabolism for Stratifying Allergic Asthma Severity.

Andrea Escolar-Peña, María Isabel Delgado-Dolset, Carmela Pablo-Torres, Carlos Tarin, Leticia Mera-Berriatua, María Del Pilar Cuesta Apausa, Heleia González Cuervo, Rinku Sharma, Alvin T Kho, Kelan G Tantisira and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrea Escolar-PeñaDepartment of Basic Medical Sciences, Institute for Applied Molecular Medicine Nemesio Díez, School of Medicine, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.ORCID 0009-0008-8197-6107
María Isabel Delgado-DolsetDepartment of Basic Medical Sciences, Institute for Applied Molecular Medicine Nemesio Díez, School of Medicine, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.ORCID 0000-0001-7924-5454
Carmela Pablo-TorresDepartment of Basic Medical Sciences, Institute for Applied Molecular Medicine Nemesio Díez, School of Medicine, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.
Carlos TarinR+D Department, Atrys Health, 08025 Madrid, Spain.ORCID 0000-0003-4385-9467
Leticia Mera-BerriatuaDepartment of Basic Medical Sciences, Institute for Applied Molecular Medicine Nemesio Díez, School of Medicine, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.
María Del Pilar Cuesta ApausaAllergy Service, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
Heleia González CuervoAllergy Service, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
Rinku SharmaDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3036-2080
Alvin T KhoComputational Health Informatics Program, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-9887-312X
Kelan G TantisiraDivision of Pediatric Respiratory Medicine, University of California San Diego and Rady Children's Hospital, San Diego, CA 92123, USA.
Michael J McGeachieDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Rocio Rebollido-RiosDepartment I of Internal Medicine, Centre of Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0002-8910-867X
Domingo BarberDepartment of Basic Medical Sciences, Institute for Applied Molecular Medicine Nemesio Díez, School of Medicine, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.ORCID 0000-0002-5488-5700
Teresa CarrilloAllergy Service, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
Elena IzquierdoDepartment of Basic Medical Sciences, Institute for Applied Molecular Medicine Nemesio Díez, School of Medicine, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.
María M EscribeseDepartment of Basic Medical Sciences, Institute for Applied Molecular Medicine Nemesio Díez, School of Medicine, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, Spain.ORCID 0000-0001-5057-5150

Funding

Advancing Transplantation Outcomes in ChildrenU01AI163072 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI David M. Briscoe · 2021 to 2026
$15.3M
Asthma Exacerbations and MicroRNA prediction: Treatment Response in an Underserved Ethnicity (AEM-TRUE)R01HL139634 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCGEACHIE, MICHAEL JOHN · 2018 to 2022
$4.3M
Omic Determinants of Longitudinal Lung Function in AsthmaR01HL155742 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A, MCGEACHIE, MICHAEL JOHN · 2021 to 2025
$3.9M
MICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4M
Genomics and Pharmacogenomics of Symptoms in AsthmaR01HL162570 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TANTISIRA, KELAN G · 2021 to 2024
$2.9M
FEDER RD16/0006/0015FEDER RD21 0002 0008Fundación Mutua Madrileña AP177712021ISCIII PI19/00044Ministry of Science and Innovation in Spain PCI2018-092930NHLBI NIH HHS R01 HL139634NHLBI NIH HHS R01 HL162570NIH HHS R01 HL127332NIH HHS R01 HL139634NIH HHS R01 HL155742NIH HHS R01 HL1612362NIH HHS R01 HL1627570NIH HHS U01 AI163072
6 · The paper itself

Abstract

The mechanisms underlying severe allergic asthma are complex and unknown, meaning it is a challenge to provide the most appropriate treatment. This study aimed to identify novel biomarkers for stratifying allergic asthmatic patients according to severity, and to uncover the biological mechanisms that lead to the development of the severe uncontrolled phenotype. By using miRNA PCR panels, we analyzed the expression of 752 miRNAs in serum samples from control subjects (

Indexed as

AsthmaBiomarkersInflammationLipid MetabolismMicroRNAsSeverity of Illness IndexAdultFemaleGene Expression ProfilingGene Expression RegulationHumansMaleMiddle AgedBiomarkersMicroRNAsallergic asthmabiomarkersmiRNAsseverity

Identifiers

PMID39273372
PMCPMC11394998

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.