Evidence map›Paper›PMID 39273510›Full record

ArticleInternational journal of molecular sciences2024

Fibrin Scaffolds Perfused with Transforming Growth Factor-β1 as an In Vitro Model to Study Healthy and Tendinopathic Human Tendon Stem/Progenitor Cells.

Maria Camilla Ciardulli, Joseph Lovecchio, Ornella Parolini, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Cyclic mechanical stimulation of TDCs improves tendon tissue maturationFrontiers in bioengineering and biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria Camilla CiardulliTranslational Nanomedicine Laboratory, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende 43, 84081 Baronissi, Italy.
Joseph LovecchioSchool of Science and Engineering, Reykjavík University, 102 Reykjavík, Iceland.ORCID 0000-0002-4721-1388
Ornella ParoliniDepartment of Life Science and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-5211-6430
Emanuele GiordanoLaboratory of Cellular and Molecular Engineering "Silvio Cavalcanti", Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi" (DEI), University of Bologna, 47522 Cesena, Italy.ORCID 0000-0002-8054-2875
Nicola MaffulliDepartment of Trauma and Orthopaedics, Faculty of Medicine and Psychology, Sant' Andrea Hospital, Sapienza University, 00189 Rome, Italy.
Giovanna Della PortaTranslational Nanomedicine Laboratory, Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende 43, 84081 Baronissi, Italy.ORCID 0000-0002-1426-0159

Funding

European Union's Horizon 2020 Research and Innovation Program under Marie Skłodowska-Curie Actions 955685
6 · The paper itself

Abstract

A limited understanding of tendon cell biology in healthy and pathological conditions has impeded the development of effective treatments, necessitating in vitro biomimetic models for studying tendon events. We established a dynamic culture using fibrin scaffolds, bioengineered with tendon stem/progenitor cells (

Indexed as

Collagen Type IFibrinStem CellsTendonsTissue ScaffoldsTransforming Growth Factor beta1Basic Helix-Loop-Helix ProteinsCells, CulturedCell SurvivalCollagen Type I, alpha 1 ChainCollagen Type IIIHumansMaleMembrane ProteinsMiddle AgedTendinopathyBasic Helix-Loop-Helix ProteinsCOL1A1 protein, humanCOL3A1 protein, humanCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIIFibrinMembrane ProteinsSCX protein, humanTNMD protein, humanTransforming Growth Factor beta13D advanced in vitro modelcytokinesdynamic culturehuman tendon/stem progenitor cellshuman transforming growth factor-β1perfusiontenogenesistissue engineering

Identifiers

PMID39273510
PMCPMC11395617

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.