Evidence mapPaperPMID 39273629Full record

ReviewInternational journal of molecular sciences2024

Hydroxychloroquine as an Adjunct Therapy for Diabetes in Pregnancy.

Nurul Iftida Basri, Padma Murthi, Rahana Abd Rahman

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nurul Iftida BasriDepartment of Obstetrics and Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-3430-0963
Padma MurthiDepartment of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0003-2535-5134
Rahana Abd RahmanDepartment of Obstetrics and Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0003-4161-6461

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review discusses the pathophysiology of diabetes in pregnancy in relation to the placental function. We review the potential use of hydroxychloroquine in improving pregnancy outcomes affected by diabetes. The review focuses on the mechanism of action of hydroxychloroquine and its potential effects on diabetes. There are several pathways in which hydroxychloroquine mediates its effects: through the inflammasome complex, inflammatory cytokines, oxidative stress, modulatory effects, and antihyperglycemic effects. As a safe drug to be used in pregnancy, it is worth exploring the possible use hydroxychloroquine as an adjunct treatment to the current therapy of diabetes in pregnancy.

Indexed as

Diabetes, GestationalHydroxychloroquineFemaleHumansHypoglycemic AgentsOxidative StressPlacentaPregnancyPregnancy OutcomeHydroxychloroquineHypoglycemic Agentsdiabeteshydroxychloroquineinflammationplacentapregnancy

Identifiers

PMID39273629
PMCPMC11395545

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.