Evidence map›Paper›PMID 39275267›Full record

ArticleNutrients2024

Multi-Omics Profiles of Small Intestine Organoids in Reaction to Breast Milk and Different Infant Formula Preparations.

Xianli Wang, Shangzhi Yang, Chengdong Zheng, Chenxuan Huang, Haiyang Yao, Zimo Guo, Yilun Wu, Zening Wang, Zhenyang Wu, Ruihong Ge and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xianli WangSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shangzhi YangSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.ORCID 0009-0005-3031-7732
Chengdong ZhengHeilongjiang Firmus Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China.
Chenxuan HuangSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.ORCID 0009-0002-3482-9020
Haiyang YaoSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Zimo GuoSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Yilun WuSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Zening WangInstitutes of Biomedical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032, China.
Zhenyang WuSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Ruihong GeSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Wei ChengSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yuanyuan YanSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shilong JiangHeilongjiang Firmus Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China.ORCID 0000-0001-6975-0844
Jianguo SunHeilongjiang Firmus Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China.
Xiaoguang LiState Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Qinggang XieHeilongjiang Firmus Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China.
Hui WangState Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Funding

National Key R&D Program of China 2022YFD2101500National Natural Science Foundation of China 82030099Science and Technology Commission of Shanghai Municipality 22DZ2303000Shanghai Public Health System Construction Three-Year Action Plan GWVI-11.1-43
6 · The paper itself

Abstract

Ensuring optimal infant nutrition is crucial for the health and development of children. Many infants aged 0-6 months are fed with infant formula rather than breast milk. Research on cancer cell lines and animal models is limited to examining the nutrition effects of formula and breast milk, as it does not comprehensively consider absorption, metabolism, and the health and social determinants of the infant and its physiology. Our study utilized small intestine organoids induced from human embryo stem cell (ESC) to compare the nutritional effects of breast milk from five donors during their postpartum lactation period of 1-6 months and three types of Stage 1 infant formulae from regular retail stores. Using transcriptomics and untargeted metabolomics approaches, we focused on the differences such as cell growth and development, cell junctions, and extracellular matrix. We also analyzed the roles of pathways including AMPK, Hippo, and Wnt, and identified key genes such as ALPI, SMAD3, TJP1, and WWTR1 for small intestine development. Through observational and in-vitro analysis, our study demonstrates ESC-derived organoids might be a promising model for exploring nutritional effects and underlying mechanisms.

Indexed as

Infant FormulaIntestine, SmallMilk, HumanOrganoidsFemaleHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaLactationMetabolomicsMultiomicsTranscriptomegrowth developmentinfant formulasmetabolomicsorganoidssmall intestinetranscriptome

Identifiers

PMID39275267
PMCPMC11397455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.