ArticleNutrients2024
Folic Acid and Selected Risk Factors for Fetal Heart Defects-Preliminary Study Results.
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Explainable machine learning model for identifying key risk factors in congenital heart disease prediction using questionnaire data: a retrospective case-control study.BMC medical informatics and decision making · 2026Article
- Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025Review
- Vitamin D and LC-PUFA and the Presence of Fetal Heart Defects-A Further Part of a Case-Control Study.Nutrients · 2024Article
- Does Folic Acid Intake Play Role as a Potential Indicator of Modifiable Maternal Risk Factors in Preconception Period?: A Cross-Sectional Study.Women's health reports (New Rochelle, N.Y.)Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe available data on the relationship between diet/folic acid and congenital heart disease (CHD) are not consistent. This study aimed to investigate the relationship between the intake and supplementation of folic acid and other selected factors in mothers and the risk of congenital heart defects in fetuses.
methodsA case-control study was conducted. The study group included pregnant women with fetuses from singleton pregnancies with prenatally diagnosed heart defects in the fetus (
resultsLack of supplementation increases the risk of heart defects in children by more than four times compared to supplementation before pregnancy (OR = 4.19;
conclusionsA history of congenital heart defects or other defects, lack of periconceptional folic acid supplementation, and lack of dietary supplementation before pregnancy were associated with congenital heart defects in the fetus. Place of residence, parents' education, lifestyle habits such as smoking and alcohol consumption, nutritional status before pregnancy, and mother's diseases did not show a significant relationship with congenital heart defects in the children. There is an urgent need to develop preventive strategies and conduct extensive public education.
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Registered trials
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