Evidence map›Paper›PMID 39276100›Full record

ArticleJournal of the American Society for Mass Spectrometry2024

An Untargeted Lipidomics Workflow Incorporating High-Resolution Demultiplexing (HRdm) Drift Tube Ion Mobility-Mass Spectrometry.

David C Koomen, Jody C May, Alexander J Mansueto, Todd R Graham, John A McLean

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. New Analytical Technologies to Resolve, Interpret, and Understand Lipid Complexity.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David C KoomenCenter for Innovative Technology, Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0003-2883-9417
Jody C MayCenter for Innovative Technology, Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0003-4871-5024
Alexander J MansuetoDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, United States.
Todd R GrahamDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, United States.
John A McLeanCenter for Innovative Technology, Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-8918-6419

Funding

Mechanisms of membrane homeostasis through protein and lipid transportR35GM144123 · NIGMS · VANDERBILT UNIVERSITY · PI TODD R GRAHAM · 2022 to 2026
$2.4M
NIGMS NIH HHS R35 GM144123
6 · The paper itself

Abstract

Global discovery lipidomics can provide comprehensive chemical information toward understanding the intricacies of metabolic lipid disorders such as dyslipidemia; however, the isomeric complexity of lipid species remains an analytical challenge. Orthogonal separation strategies, such as ion mobility (IM), can be inserted into liquid chromatography-mass spectrometry (LC-MS) untargeted lipidomic workflows for additional isomer separation and high-confidence annotation, and the emergence of high-resolution ion mobility (HRIM) strategies provides marked improvements to the resolving power (

Indexed as

Ion Mobility SpectrometryLipidomicsLipidsAlgorithmsAnimalsChromatography, LiquidIsomerismMass SpectrometryMiceMice, Inbred C57BLWorkflowLipidsHadamard transformHRIMmurine dyslipidemiapeak deconvolutionuntargeted lipidomics

Identifiers

PMID39276100
PMCPMC11450926

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.