Metformin × all-cause mortality

SynthesisEndocrine2025

Clinical outcomes in type 2 diabetes patients with chronic heart failure treated with metformin: a meta-analysis.

Wenxia Huang et al.PubMed ↗Publisher ↗

What the trial testedas reported · 20,595 people · 2025

Not counted

Reduced deaths

−28%−40% to −13%

Bigger than 8 in 10 for all-cause mortality

As reported

RR 0.72, 95% CI 0.60–0.87 · the paper's word: All-cause mortality

Not counted

Reduced cardiovascular events

−48%−71% to −8%

Bigger than 9 in 10 for cardiovascular events

As reported

RR 0.52, 95% CI 0.29–0.92

Two numbers in the abstract

the abstract, start to end

risk of all-cause mortality (RR = 0.72, 95%CI: 0.60-0.87) and a notably lower risk of cardiovascular mortality (RR = 0.52, 95%CI:0.29-0.92).

← favours treatmentfavours comparator →
could be chance
All-cause mortality
RR 0.720.60–0.87
Cardiovascular events
RR 0.520.29–0.92
MetforminCardiovascular eventsAll-cause mortality
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4 papers cite it

2024
2025
2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 39277567