Evidence map›Paper›PMID 39278095›Full record

ArticleBiochemical and biophysical research communications2024

A novel interaction between RNA m

Jing Xu, Charukesi Sivakumar, Charles W Ryan, Rajesh C Rao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jing XuDepartment of Ophthalmology and Visual Science, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA.
Charukesi SivakumarDepartment of Ophthalmology and Visual Science, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA; Department of Pathology, University of Michigan, Ann Arbor, MI, 48105, USA.
Charles W RyanMedical Scientist Training Program, University of Michigan, Medical School, Ann Arbor, MI, 48105, USA.
Rajesh C RaoDepartment of Ophthalmology and Visual Science, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA; Department of Pathology, University of Michigan, Ann Arbor, MI, 48105, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48105, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48105, USA; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48105, USA; Center for RNA Biomedicine, University of Michigan, Ann Arbor, 48105, USA; A. Alfred Taubman Medical Research Institute, University of Michigan, Ann Arbor, MI, 48105, USA; Section of Ophthalmology, Surgical Service, Veterans Administration Ann Arbor Healthcare System, Ann Arbor, MI, 48105, USA. Electronic address: rajeshr@med.umich.edu.

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Molecular Determinants for WDR5-Driven Transcriptional Regulation at Lineage-Specifying Genes During RetinogenesisR01EY030989 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, RAJESH C. · 2020 to 2024
$2.2M
NEI NIH HHS P30 EY007003NEI NIH HHS R01 EY030989NIGMS NIH HHS T32 GM007337
6 · The paper itself

Abstract

Regulation of gene expression is achieved through the modulation of regulatory inputs both pre- and post-transcriptionally. Methyltransferase-like 3 (METTL3) is a key player in pre-mRNA processing, actively catalyzing N6-methyladenosine (m6A). Among the most enriched mRNA targets of METTL3 is the Ras Responsive Element Binding Protein 1 (RREB1), a transcription factor which functions to govern cell fate, proliferation and DNA repair. Here, we show a novel interaction between METTL3 and RREB1. Further examination of this interaction indicates that METTL3's N-terminus is the primary interacting domain. Our findings uncover a novel interacting partner of METTL3, providing further insights into METTL3's regulatory network.

Indexed as

MethyltransferasesTranscription FactorsAdenosineDNA-Binding ProteinsHEK293 CellsHumansProtein BindingAdenosineDNA-Binding ProteinsMethyltransferasesMETTL3 protein, humanN-methyladenosineRREB1 protein, humanTranscription Factors

Identifiers

PMID39278095
PMCPMC12643035

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.