Synthesis and evaluation of nanosized aluminum MOF encapsulating Umbelliferon: assessing antioxidant, anti-inflammatory, and wound healing potential in an earthworm model.

Rabab M Thabit, Fatma El-Zahraa A Abd El-Aziz, A Abu El-Fadl, A A Abu-Sehly, Ahmed M Sayed

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Article in BMC biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Synthesis of ZIF-67 Nanoparticles for Camel Whey Protein Delivery: Promising Antioxidant, Anti-inflammatory, Anticancer Effects, and Anti-biofilm Activity.Molecular biotechnology · 2026
Article

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5 · Who and what money

Authors and funding

5 authors.

Rabab M ThabitPhysics Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

Fatma El-Zahraa A Abd El-AzizDepartment of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

A Abu El-FadlPhysics Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

A A Abu-SehlyPhysics Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt.

Ahmed M SayedChemistry Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt. ahmed.sayed@aun.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoporous aluminum metal-organic framework (Al-MOF) was synthesized via solvothermal methods and employed as a carrier matrix for in vitro drug delivery of Umbelliferon (Um). The encapsulated Um was gradually released over seven days at 37 °C, using simulated body fluid phosphate-buffered saline (PBS) at pH 7.4 as the release medium. The drug release profile suggests the potential of Al-MOF nanoparticles as effective drug delivery carriers. Structural and chemical analyses of Um-loaded Al-MOF nanoparticles (Um-Al MOF) were conducted using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffractometry (XRD), and ultraviolet-visible (UV-Vis) spectroscopy. Thermal gravimetric analysis (TGA) was employed to investigate the thermal stability of the Al-MOF nanoparticles, while Transmission Electron Microscopy (TEM) was utilized to assess their morphological features. Um-Al MOF nanoparticles demonstrated notable antioxidant and anti-inflammatory properties compared to Um and Al-MOF nanoparticles individually. Moreover, they exhibited significant enhancement in wound healing in an earthworm model. These findings underscore the potential of Al-MOF nanoparticles as a promising drug delivery system, necessitating further investigations to explore their clinical applicability.

Indexed as

AluminumAnti-Inflammatory AgentsAntioxidantsMetal-Organic FrameworksOligochaetaUmbelliferonesWound HealingAnimalsDrug CarriersDrug LiberationNanoparticles7-hydroxycoumarinAluminumAnti-Inflammatory AgentsAntioxidantsDrug CarriersMetal-Organic FrameworksUmbelliferonesAl-MOFBiological activitiesDrug deliveryEarthwormsUmbelliferonWound healing

Identifiers

PMID39278901

DOI10.1186/s12896-024-00889-8

PMCPMC11403860

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Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.