ReviewCurrent medicinal chemistry2025
Changes in Energy Dynamics in Arsenic Exposure based Neurotoxicity: A Comprehensive Review.
Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
backgroundThe by-product of naturally occurring rock, soil with different agricultural and industrial processes contaminated groundwater with a toxic metalloid- Arsenic (As
aimThe present study emphasizes evaluating the presence of oxidative stress and excessive generation of reactive oxygen species (ROS) resulting in mitochondrial dysfunction and caspase activation followed by apoptosis due to arsenic-induced neurotoxicity along with epigenetic modifications at different molecular targets.
methodsPublished articles available on PubMed and Scopus were studied and summarized.
resultsThe precise mechanism causing arsenic-induced neurotoxicity at a critical stage of brain development is still unknown, while increased oxidative stress led to mitochondrial dysfunctions which are known to play a prominent role in this. AMPK acts as a metabolic checkpoint and restores ATP levels through a different anabolic pathway in energy starvation. At the same time, arsenic-induced AMPK activation leads to autophagy and neuronal cell death.
conclusionThis review summarized the molecular mechanisms involved in arsenic-induced neurotoxicity, which can help to develop suitable future ameliorative and therapeutic strategies.
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Registered trials
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