Evidence map›Paper›PMID 39279769›Full record

ArticleNeuro-oncology practice2024

Assessing the reporting quality of pediatric neuro-oncology protocols, abstracts, and trials: Adherence to the SPIRIT and CONSORT statements.

Joshua S Suppree, Sophia Hart, Sumirat M Keshwara, Sandhya Trichinopoly Krishna, Conor S Gillespie, George E Richardson, Mohammad A Mustafa, Conor L Mallucci, Barry Pizer, James Hayden and 3 more

Abstract read
In one paragraph

Article in Neuro-oncology practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joshua S SuppreeSchool of Medicine, University of Liverpool, Liverpool, UK.
Sophia HartDepartment of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Sumirat M KeshwaraDepartment of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Sandhya Trichinopoly KrishnaDepartment of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Conor S GillespieSchool of Medicine, University of Liverpool, Liverpool, UK.
George E RichardsonSchool of Medicine, University of Liverpool, Liverpool, UK.
Mohammad A MustafaDepartment of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Conor L MallucciDepartment of Pediatric Neurosurgery, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Barry PizerUniversity of Liverpool, Liverpool, UK.
James HaydenDepartment of Pediatric Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Abdurrahman I IslimDepartment of Pharmacology & Therapeutics, Institute of Systems, Molecular, & Integrative Biology, University of Liverpool, Liverpool, UK.
Michael D JenkinsonDepartment of Pharmacology & Therapeutics, Institute of Systems, Molecular, & Integrative Biology, University of Liverpool, Liverpool, UK.
Christopher P MillwardDepartment of Pharmacology & Therapeutics, Institute of Systems, Molecular, & Integrative Biology, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0001-7727-1157

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: It is of vital importance to comprehensively and transparently report clinical trial activity. The SPIRIT 2013 and CONSORT 2010 statements exist to define items to be reported in clinical trial protocols and randomized controlled trials, respectively. The aim of this methodological review was to assess the reporting quality of pediatric neuro-oncology trial protocols and trial result articles. Methods: Published trial protocols and phase II/III trial result articles relating to pediatric brain tumors (published after the introduction of the SPIRIT 2013 statement), were identified through searches of 4 electronic bibliographic databases. The reporting quality of included trial protocols and result articles was assessed against the aforementioned statements. In addition, the CONSORT-A checklist was used to assess the abstracts of trial result articles. Percentage adherence was calculated for each article. Results: Nine trial protocols, 68 phase II trials, and 8 phase III trial result articles were included. Mean adherence of trial protocols to the SPIRIT statement was 76.8% ( Conclusions: The reporting quality of pediatric neuro-oncology trial protocols and trial result articles requires improvement, particularly in the areas of randomization and blinding. This is consistent with our previously published findings following similar assessment of reporting quality for adult neuro-oncology trial protocols and result articles.

Indexed as

clinical trialCONSORTCONSORT-ASPIRIT

Identifiers

PMID39279769
PMCPMC11398948

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.