Evidence map›Paper›PMID 39280279›Full record

ArticleNarra J2024

A fruit fly-based approach to unraveling enteropathy-causing pharmaceuticals.

Muhammad R Pratama, Elly Wahyudin, Tenri Zad Putri, Widya Hardiyanti, Dewita Fatiah, Rizkya Chaeratunnisa, Nurdewi N Bapulo, Nadila P Latada, Mukarram Mudjahid, Firzan Nainu

Abstract read
In one paragraph

Article in Narra J, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Dual effects ofNarra J · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad R PratamaPostgraduate Program in Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Elly WahyudinDepartmentof Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Tenri Zad PutriPostgraduate Program in Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Widya HardiyantiPostgraduate Program in Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Dewita FatiahPostgraduate Program in Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Rizkya ChaeratunnisaUndergraduate Program in Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Nurdewi N BapuloPostgraduate Program in Biomedical Science, Graduate School of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
Nadila P LatadaUnhas Fly Research Group, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Mukarram MudjahidDepartmentof Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
Firzan NainuDepartmentof Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enteropathy is a gastrointestinal disorder characterized by inflammation in the small intestine and one of the causes of enteropathy is the side effects of certain drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs). The mechanism of NSAIDs, such as indomethacin, could inhibit prostaglandin synthesis, leading to a decrease in mucus production and small intestine integrity. To test the effects of a drug, it is necessary to undergo preclinical testing using animal models. Commonly used animal models such as mice and rats have several drawbacks including high cost, ethical issues, and long lifespan. Therefore, alternatives such as using invertebrate animals like

Indexed as

Anti-Inflammatory Agents, Non-SteroidalDrosophila melanogasterIndomethacinIntestinal DiseasesAnimalsDisease Models, AnimalSuperoxide DismutaseAnti-Inflammatory Agents, Non-SteroidalIndomethacinSuperoxide Dismutaseenteropathyfruit flyIntestineNSAIDSmurf assay

Identifiers

PMID39280279
PMCPMC11394174

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.